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Table 1 Overview of the selected SNPs and their genotyping performance

From: Treatment outcome of chronic low back pain and radiographic lumbar disc degeneration are associated with inflammatory and matrix degrading gene variants: a prospective genetic association study

SNP* Gene HWE** p-value GRS %† Alleles‡ MAF§ cases MAF ∞ reported
rs2071375 IL1A 1.0 100 T/C 0.25 0.21
rs2287037 IL18R1 0.73 100 T/C 0.32 0.39
rs1420100 IL18RAP 1.0 100 A/C 0.50 0.51
rs1420106 IL18RAP 0.7 100 A/G 0.25 0.21
rs917997 IL18RAP 1.0 100 T/C 0.27 0.20
rs5277 COX2 0.81 100 G/C 0.19 0.21
rs4140564 COX2 1.0 100 G/A 0.05 0.08
rs72520913 MMP3 0.09 100 A/C 0.50 Not reported
  1. * Single nucleotide polymorphism; ** Hardy-Weinberg equilibrium; Genotype success rate;
  2. Minor/Major alleles; § Minor allele frequency; MAF HapMap-CEU European.