Skip to main content

Table 3 Reported Incident Malignancy Types by Adjudication

From: Malignancy validation in a United States registry of rheumatoid arthritis patients

Organ or Type of Malignancy Physician Form Records Review – Definite* Records Review – Probable** Records Review – Possible*** Records Review – Not Malignancy or Not An Incident Malignancy****
(Total: 461) (Total: 234) (Total: 69) (Total: 101) (Total: 57)
Skin – NMSC1 154 71 (46.1%) 35 (22.7%) 42 (27.3%) 6 (3.9%)
Skin – Melanoma 9 5 (55.6%) 1 (11.1%) 2 (22.2%) 1 (11.1%)
Skin – Other2 5 4 (80%) 1 (20%) 0 0
Breast 59 41 (69.5%) 3 (5.1%) 13 (22.0%) 2 (3.4%)
Hematologic4 42 32 (76.2%) 7 (16.7%) 3 (7.1%) 0
Other3 49 1 (2.0%) 0 7 (14.3%) 41 (83.7%)
Prostate 38 21 (55.3%) 4 (10.5%) 11 (29%) 2 (5.3%)
Lung 25 11 (44.0%) 2 (8%) 9 (36%) 3 (12%)
Colon5 21 13 (61.9%) 5 (23.8%) 3 (14.3%) 0
Thyroid 9 3 (33.3%) 5 (55.5%) 1 (11.1%) 0
Bladder 12 6 (50%) 2 (16.7%) 3 (25%) 1 (8.3%)
Head and Neck6 7 4 (57.1%) 2 (28.6%) 1 (14.3%) 0
Uterine 5 3 (60%) 0 1 (20%) 1 (20%)
Upper GI7 4 4 (100%) 0 0 0
Renal 4 2 (50%) 1 (25%) 1 (25%) 0
Cervical 3 1 (33.3%) 0 2 (66.7%) 0
Ovarian 3 2 (66.7%) 0 1 (33.3%) 0
Pancreatic 2 2 (100%) 0 0 0
Bile duct 1 1 (100%) 0 0 0
Parotid Gland 2 1 (50%) 0 1 (50%) 0
Brain 2 1 (50%) 1 (50%) 0 0
Hepatic 2 2 (100%) 0 0 0
Peritoneum 1 1 (100%) 0 0 0
Gallbladder 1 1 (100%) 0 0 0
Angiosarcoma 1 1 (100%) 0 0 0
  1. 1) Includes 47 squamous cell, 91 basal cell, and 16 unspecified.
  2. 2) Includes vulvar, anal, perianal, intergluteal skin cancers.
  3. 3) Includes all malignancies with unspecified primary organ.
  4. 4) Includes 36 lymphomas, 1 Myeloma, 3 Leukemia, 2 Myelodysplasia.
  5. 5) Includes Rectal, anal, bowel, small intestine, appendix.
  6. 6) Includes Larynx, tongue, vocal cord, nasopharyngeal.
  7. 7) Includes esophageal and gastric.
  8. * Definite malignancy defined as date of diagnosis and histology confirmed on records from an oncologist, biopsy, radiation oncologist, or appropriate specialist for specific cancers.
  9. ** Probable malignancy defined as date of diagnosis and histology confirmed from records other than oncologist, biopsy, radiation oncologist, or appropriate specialist.
  10. *** Possible malignancy defined as submission of records confirming either date of
  11. diagnosis or histology but not both.
  12. **** Not Malignancy or Not An Incident Malignancy defined as records confirming pathology were benign or date of diagnosis prior to enrollment in CORRONA