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Table 3 Reported Incident Malignancy Types by Adjudication

From: Malignancy validation in a United States registry of rheumatoid arthritis patients

Organ or Type of Malignancy

Physician Form

Records Review – Definite*

Records Review – Probable**

Records Review – Possible***

Records Review – Not Malignancy or Not An Incident Malignancy****

(Total: 461)

(Total: 234)

(Total: 69)

(Total: 101)

(Total: 57)

Skin – NMSC1

154

71 (46.1%)

35 (22.7%)

42 (27.3%)

6 (3.9%)

Skin – Melanoma

9

5 (55.6%)

1 (11.1%)

2 (22.2%)

1 (11.1%)

Skin – Other2

5

4 (80%)

1 (20%)

0

0

Breast

59

41 (69.5%)

3 (5.1%)

13 (22.0%)

2 (3.4%)

Hematologic4

42

32 (76.2%)

7 (16.7%)

3 (7.1%)

0

Other3

49

1 (2.0%)

0

7 (14.3%)

41 (83.7%)

Prostate

38

21 (55.3%)

4 (10.5%)

11 (29%)

2 (5.3%)

Lung

25

11 (44.0%)

2 (8%)

9 (36%)

3 (12%)

Colon5

21

13 (61.9%)

5 (23.8%)

3 (14.3%)

0

Thyroid

9

3 (33.3%)

5 (55.5%)

1 (11.1%)

0

Bladder

12

6 (50%)

2 (16.7%)

3 (25%)

1 (8.3%)

Head and Neck6

7

4 (57.1%)

2 (28.6%)

1 (14.3%)

0

Uterine

5

3 (60%)

0

1 (20%)

1 (20%)

Upper GI7

4

4 (100%)

0

0

0

Renal

4

2 (50%)

1 (25%)

1 (25%)

0

Cervical

3

1 (33.3%)

0

2 (66.7%)

0

Ovarian

3

2 (66.7%)

0

1 (33.3%)

0

Pancreatic

2

2 (100%)

0

0

0

Bile duct

1

1 (100%)

0

0

0

Parotid Gland

2

1 (50%)

0

1 (50%)

0

Brain

2

1 (50%)

1 (50%)

0

0

Hepatic

2

2 (100%)

0

0

0

Peritoneum

1

1 (100%)

0

0

0

Gallbladder

1

1 (100%)

0

0

0

Angiosarcoma

1

1 (100%)

0

0

0

  1. 1) Includes 47 squamous cell, 91 basal cell, and 16 unspecified.
  2. 2) Includes vulvar, anal, perianal, intergluteal skin cancers.
  3. 3) Includes all malignancies with unspecified primary organ.
  4. 4) Includes 36 lymphomas, 1 Myeloma, 3 Leukemia, 2 Myelodysplasia.
  5. 5) Includes Rectal, anal, bowel, small intestine, appendix.
  6. 6) Includes Larynx, tongue, vocal cord, nasopharyngeal.
  7. 7) Includes esophageal and gastric.
  8. * Definite malignancy defined as date of diagnosis and histology confirmed on records from an oncologist, biopsy, radiation oncologist, or appropriate specialist for specific cancers.
  9. ** Probable malignancy defined as date of diagnosis and histology confirmed from records other than oncologist, biopsy, radiation oncologist, or appropriate specialist.
  10. *** Possible malignancy defined as submission of records confirming either date of
  11. diagnosis or histology but not both.
  12. **** Not Malignancy or Not An Incident Malignancy defined as records confirming pathology were benign or date of diagnosis prior to enrollment in CORRONA