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Table 3 Single marker association analysis of COMT SNPs and 7–11 years follow-up VAS LBP change in 93 patients, a recessive genetic model

From: Genetic contribution of catechol-O-methyltransferase variants in treatment outcome of low back pain: a prospective genetic association study

 

rs4633

rs4680

 

Mean difference (β)† (95% CI)

p value

Mean difference (β) (95% CI)

p value

SNP*§

13.5 (1.9, 25.0)

0.02

14.2 (2.7, 25.6)

0.02

Age

0.7 (0.05, 1.3)

0.04

0.7 (0.08, 1.4)

0.03

Gender

6.9 (−3.9, 17.7)

0.21

7.8 (−2.8, 18.5)

0.15

Fusion

11.82 (0.8, 22.8)

0.04

10.9 (0.1, 21.6)

0.05

Analgesics

18.4 (7.2, 29.6)

0.002

18.6 (7.5, 29.7)

0.001

Anxiety and depression

14.6 (3.2, 26.0)

0.01

15.4 (4.1, 26.7)

0.008

  1. * Single nucleotide polymorphism, † mean difference in pain score (for age β is the mean difference in pain score per year); § Recessive genotype (rs4633: T/T; rs4680: A/A).
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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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