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Table 3 Single marker association analysis of COMT SNPs and 7–11 years follow-up VAS LBP change in 93 patients, a recessive genetic model

From: Genetic contribution of catechol-O-methyltransferase variants in treatment outcome of low back pain: a prospective genetic association study

  rs4633 rs4680
  Mean difference (β)† (95% CI) p value Mean difference (β) (95% CI) p value
SNP*§ 13.5 (1.9, 25.0) 0.02 14.2 (2.7, 25.6) 0.02
Age 0.7 (0.05, 1.3) 0.04 0.7 (0.08, 1.4) 0.03
Gender 6.9 (−3.9, 17.7) 0.21 7.8 (−2.8, 18.5) 0.15
Fusion 11.82 (0.8, 22.8) 0.04 10.9 (0.1, 21.6) 0.05
Analgesics 18.4 (7.2, 29.6) 0.002 18.6 (7.5, 29.7) 0.001
Anxiety and depression 14.6 (3.2, 26.0) 0.01 15.4 (4.1, 26.7) 0.008
  1. * Single nucleotide polymorphism, † mean difference in pain score (for age β is the mean difference in pain score per year); § Recessive genotype (rs4633: T/T; rs4680: A/A).