Table 1 Genotype distribution, relative allele frequencies and haplotype data of HOXD9 tag SNPs
Single Marker | Allele | Genotype | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
rs711822 | A (freq) | G (freq) | A/A (freq) | A/G (freq) | G/G (freq) | ||||||
case | 164 (0.392) | 254 (0.608) | 27 (0.129) | 110 (0.526) | 72 (0.344) | ||||||
unilateral | bilateral | unilateral | bilateral | unilateral | bilateral | unilateral | bilateral | unilateral | bilateral | ||
152(0.384) | 12(0.545) | 244(0.616) | 10(0.455) | 24(0.121) | 3(0.273) | 104(0.525) | 6(0.545) | 70(0.354) | 2(0.182) | ||
control | 131 (0.379) | 215 (0.621) | 27 (0.156) | 77 (0.445) | 69 (0.399) | ||||||
X 2 = 0.15, df = 1, P = 0.697 | X 2= 2.52, df = 2, P = 0.284 | ||||||||||
rs711822 | A (freq) | G (freq) | A/A (freq) | A/G (freq) | G/G (freq) | ||||||
case | 258 (0.617) | 160 (0.383) | 73 (0.349) | 112 (0.536) | 24 (0.115) | ||||||
unilateral | bilateral | unilateral | bilateral | unilateral | bilateral | unilateral | bilateral | unilateral | bilateral | ||
246(0.621) | 12(0.545) | 150(0.378) | 10(0.455) | 70(0.354) | 3(0.273) | 106(0.535) | 6(0.545) | 22(0.111) | 2(0.182) | ||
control | 207 (0.609) | 133 (0.391) | 69 (0.406) | 69 (0.406) | 32 (0.188) | ||||||
X 2 = 0.056, df = 1, P = 0.813 | X 2= 7.54, df = 2, P = 0.023 | ||||||||||
P = 0.045, OR = 1.79,95 % CI: 1.01-3.17 by dominant mode | |||||||||||
Haplotype | G-A | A-G | G-G | A-A | |||||||
rs711822-rs711819 | Freq | 0.595 | 0.366 | 0.02 | 0.019 | ||||||
case | control | case | control | case | control | case | control | ||||
0.584 | 0.607 | 0.358 | 0.376 | 0.025 | 0.015 | 0.032 | 0 | ||||
P value | 0.5533 | 0.6454 | 0.3716 | 0.0045 | |||||||