Local treatment of a bone graft by soaking in zoledronic acid inhibits bone resorption and bone formation. A bone chamber study in rats

Table 5 Bone Volume/Total Volume (BV/TV)

Group	Median BV/TV (%)	Range (%)	Ratio graft bone/total bone (%)
1. Saline control, n = 10	11	4-47	23
2. Short soaking time, n = 10	60	42-74	29
3. Long soaking time, n = 9	61	53-68	18
4. Topical zoledronic acid, no rinse, n = 10	54	40-65	24
5. Zoledronic acid systemic injection, n = 10	41	30-57	25

Resorption of bone expressed as the amount of remaining bone in the remodelled area of the graft. The ratio between old graft bone and the total amount of bone including the newly formed bone is also presented.

ISSN: 1471-2474