Table 1 Summary of measures to be collected

Function

Research Clinic Questionnaire (participant reported)

Michigan Hand Outcomes Questionnaire (MHQ)– overall Hand function score (0–100)

0, 4, 12

Michigan Hand Outcomes Questionnaire (MHQ)– overall score (0–100)

Pain

Research Clinic Questionnaire

Pain sub-scale of MHQ (0–100; high score is worse)

0, 4, 12

‘Troublesomeness’ rating (0–20; high score is worse)

Impairment

Research Clinic Examination (performed by outcome assessor)

Joint deformity (MCPJ only) – goniometer (Degrees; high score is worse)

0, 4, 12

Wrist range of motion (flexion/extension) – goniometer (Degrees)

Finger range of motion (combined flexion and combined extension) – Ruler (mm; high score is worse for combined flexion)

Thumb opposition range of motion - observation (0–10)

Dexterity - timed 9 hole peg test (Seconds; high score is worse)

Grip and Pinch Strength – dynamometer (Newtons)

Disease Activity

Medical Records Research Clinic Examination

Erythrocyte sedimentation rate (ESR – mm/h) and/or C-Reactive protein (CRP – mg/l) blood test

0, 4, 12

Hand and wrist joint tenderness and swelling count – examination (0–22; high score is worse)

Health-related Quality of Life

Research Clinic Questionnaire

SF-12(0-100)

0, 4, 12

EuroQol EQ-5D (health utility)(0–1)

Self-efficacy

Research Clinic Questionnaire

7 item questionnaire

0, 4, 12

Satisfaction

Research Clinic Questionnaire

Treatment satisfaction item

4,12

Satisfaction sub-scale of MHQ (0–100)

Global Change

Research Clinic Questionnaire

Participant-rated global change question(7 point Likert scale)

4, 12

Adherence

Research Clinic Questionnaire

5 item questionnaire

0, 4, 12

Economics

Research Clinic Questionnaire

Resource use questionnaire

4, 12