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Table 3 Comparison of AS subjects with respect to disease activity

From: Biomarkers and cytokines of bone turnover: extensive evaluation in a cohort of patients with ankylosing spondylitis

  Active patients(BASDAI ≥ 4; n= 38) Inactive patients(BASDAI < 4; n= 17) p value
IL-6 (pg/mL) 20 (6–545) 15 (5–277) 0.2
IFNγ (pg/mL) 0.002 (0.002–1.96) 0.002 (0.002–0.89) 0.7
BAP (U/L) 28 (13–107) 30 (15–49) 0.3
Vitamin D (nM) 89 (4–266) 77 (12–240) 0.6
NTX (nM, bone collagen equivalent) 87 (56–131) 81 (52–188) 0.7
TRAP 5 (U/L) 3.7 (2.2–5.8) 3.9 (2.4–6.6) 0.4
hPTH (pg/mL) 46 (44–170) 77 (45–130) 0.08
sRANKL (pmol/L) 264 (101–956) 350 (158–1598) 0.2
OPG (pg/mL) 367 (52–1118) 274 (71–592) 0.004
sRANKL/OPG 0.79 (0.14–4.5) 1.16 (0.4–22.6) 0.02
Sclerostin (pmol/L) 70 (49–126) 75 (48–123) 0.7
sFRP1 (ng/mL) 0.15 (0.1–17) 0.1 (0.1–0.2) 0.5
DKK1 (pg/mL) 93 (26–370) 130 (17–771) 0.5
BASRI-hip 0 (0–4) 0.5 (0–4) 0.2
BASRI-spine 5.5 (2–12) 7 (2–12) 0.3
BASMI 4 (1–9) 2.5 (1–9) 0.7
BMD-Lumbar spine (g/cm2) 0.9 (0.7–1.4) 0.9 (0.7–1.6) 0.8
BMD-Femoral neck (g/cm2) 0.7 (0.6–1.1) 0.8 (0.5–1) 0.9
  1. Data are presented as the median with minimum and maximum values. BASDAI= Bath ankylosing spondylitis disease activity index, IL-6= interleukin 6, IFNγ= interferon-gamma, BAP= bone-specific alkaline phosphatase, NTX= cross-linked N-telopeptide of type I collagen, TRAP 5= serum band 5 tartrate-resistant acid phosphatase, hPTH= human parathyroid hormone, sRANKL= soluble receptor activator of nuclear factor kappa-B ligand, OPG= osteoprotegerin, sFRP1= secreted frizzled-related protein 1, DKK1= Dickkopf-related protein 1, BASRI= Bath Ankylosing spondylitis radiologic index, BASMI= Bath ankylosing spondylitis metrology index.