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Table 2 Comparison of AS subjects with respect to treatment type

From: Biomarkers and cytokines of bone turnover: extensive evaluation in a cohort of patients with ankylosing spondylitis

  Anti-TNF treatment(n = 23) Conventional treatment(n = 32) p value
BASFI 3.7 (1.5–7.7) 3.8 (0.1–8.8) 0.4
BASDAI 4 (1.3–8.1) 5.5 (1–9) 0.08
BASRI-hip 0 (0–4) 0 (0–2.5) 0.1
BASRI-spine 7.5 (2–12) 5.5 (2–12) 0.09
BASMI 4 (1–9) 2 (1–9) 0.003
BMD-Lumbar spine (g/cm2) 1 (0.7–1.6) 0.9 (0.8–1.4) 0.3
BMD-Femoral neck (g/cm2) 0.8 (0.6–1) 0.8 (0.5–1.1) 0.5
IL-6 (pg/mL) 13 (5–545) 20 (6–300) 0.9
IFNγ (pg/ml) 0.002 (0.002–0.03) 0.002 (0.002–1.96) 0.6
BAP (U/L) 33 (17–107) 28 (13–47) 0.04
Vitamin D (nM) 84 (12–266) 92 (4–244) 0.9
NTX (nM, bone collagen equivalent) 78 (52–188) 83 (64–114) 0.4
TRAP 5 (U/L) 4 (2.3–5.8) 3.7 (2.3–6.6) 0.3
hPTH (pg/mL) 46 (44–130) 46 (44–170) 0.8
sRANKL (pmol/L) 284 (103–1598) 285 (101–956) 0.5
OPG (pg/mL) 274 (52–1080) 384 (84–1118) 0.04
sRANKL/OPG 1.28 (0.2–22.6) 0.73 (0.14–4.5) 0.03
Sclerostin (pmol/L) 75 (48–95) 68 (49–126) 0.6
sFRP1 (ng/mL) 0.1 (0.1–17) 0.2 (0.1–0.4) 0.1
DKK1 (pg/mL) 108 (39–771) 87 (17–370) 0.03
  1. Data are presented as the median with minimum and maximum values. BASFI= Bath ankylosing apondylitis functional index, BASDAI= Bath ankylosing spondylitis disease activity index, BASMI= Bath ankylosing spondylitis metrology index, BASRI= Bath Ankylosing spondylitis radiologic index, IL-6= interleukin 6, IFNγ= interferon-gamma, BAP= bone-specific alkaline phosphatase, NTX= cross-linked N-telopeptide of type I collagen, TRAP 5= serum band 5 tartrate-resistant acid phosphatase, hPTH= human parathyroid hormone, sRANKL= soluble receptor activator of nuclear factor kappa-B ligand, OPG= osteoprotegerin, sFRP1= secreted frizzled-related protein 1, DKK1= Dickkopf-related protein 1.