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Figure 2 | BMC Musculoskeletal Disorders

Figure 2

From: A method to screen and evaluate tissue adhesives for joint repair applications

Figure 2

Establishing the test system. (a) Different modes of operation were applied to determine adhesive characteristics of fibrin. Varying bonding strengths were detected in the specific tests with highest values in fixing transplants and lowest in bonding bone tissue. T-test: 30 s vs. 60 s, * p < 0.05. (b) The reusability of tissue cylinders was investigated for cartilage. Three different biological replicates (set 1–3) of cartilage cylinders were investigated. After each measurement with fibrin, the adhesive was removed and a new control measurement with PBS was performed. This proceeding was repeated 10 times. Technical variations for each set range from 0.4 and 2.4 kPa, but do not increase with frequency of use suggesting that the cylinders can be reused. Differences according to biological variation are marginal (mean values range from 1.16 – 1.34 kPa, grey bar) demonstrating good reproducibility of the preparation method.

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