Incidence rates (per 100,000 patient-years) of influenza | Incidence rate ratios adjusted for baseline characteristics (95% CI) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Parameter | Age categories | Males | Females | Total | Males | Females | Total | |||
RA cases | Controls | RA cases | Controls | RA cases | Controls | |||||
Influenza | 18–29 | 495.81 | 336.70 | 534.54 | 444.42 | 522.13 | 409.48 | 1.72 (0.50, 5.94) | 1.54 (0.70, 3.38) | 1.57 (0.81, 3.03) |
30–39 | 761.26 | 347.99 | 633.31 | 387.97 | 670.90 | 375.64 | 2.07 (0.97, 4.38) | 1.54 (0.93, 2.54) | 1.65 (1.09, 2.51) | |
40–49 | 521.10 | 379.23 | 515.93 | 498.87 | 517.57 | 459.64 | 1.06 (0.62, 1.82) | 0.88 (0.62, 1.24) | 0.92 (0.69, 1.24) | |
50–59 | 358.50 | 245.10 | 381.06 | 357.66 | 373.58 | 319.45 | 1.38 (0.83, 2.32) | 0.94 (0.68, 1.30) | 1.06 (0.80, 1.38) | |
60–69 | 299.32 | 106.51 | 366.56 | 200.68 | 342.11 | 165.94 | 2.44 (1.13, 5.26) | 1.75 (1.11, 2.76) | 1.94 (1.31, 2.86) | |
≥70 | 309.20 | 238.81 | 314.97 | 252.78 | 312.93 | 247.95 | 0.97 (0.48, 1.96) | 0.97 (0.58, 1.62) | 0.98 (0.64, 1.48) | |
Overall | 393.91 | 245.31 | 417.18 | 337.69 | 409.33 | 306.12 | 1.43 (1.09, 1.88) | 1.13 (0.95, 1.35) | 1.22 (1.05, 1.41) | |
Influenza complications a | 18–29 | 70.05 | 0 | 0 | 0 | 22.45 | 0 | – | – | – |
30–39 | 57.49 | 0 | 71.98 | 0 | 67.71 | 0 | – | – | – | |
40–49 | 38.61 | 32.78 | 71.96 | 31.89 | 61.36 | 32.18 | 0.45 (0.06, 3.44) | 1.45 (0.43, 4.93) | 1.10 (0.39, 3.07) | |
50–59 | 59.28 | 19.50 | 55.02 | 20.01 | 56.43 | 19.84 | 1.39 (0.26, 7.46) | 2.06 (0.65, 6.47) | 1.83 (0.71, 4.69) | |
60–69 | 59.53 | 35.44 | 63.02 | 13.79 | 61.76 | 21.77 | 1.08 (0.25, 4.70) | 3.17 (0.67, 14.97) | 2.15 (0.77, 6.0) | |
≥70 | 180.81 | 79.38 | 122.12 | 50.39 | 142.86 | 60.42 | 1.18 (0.39, 3.63) | 1.76 (0.65, 4.74) | 1.50 (0.71, 3.14) | |
Overall | 80.28 | 34.08 | 71.95 | 23.55 | 74.76 | 27.15 | 1.30 (0.64, 2.63) | 2.17 (1.22, 3.86) | 1.82 (1.16, 2.81) | |
Influenza – no DMARDs or biologics | 18–29 | 541.94 | 343.41 | 609.33 | 456.87 | 587.11 | 419.88 | 1.72 (0.50, 5.49) | 1.54 (0.71, 3.38) | 1.57 (0.81, 3.04) |
30–39 | 804.93 | 352.17 | 670.75 | 377.68 | 710.76 | 369.80 | 2.07 (0.97, 4.38) | 1.61 (0.97, 2.68) | 1.71 (1.12, 2.61) | |
40–49 | 516.81 | 383.82 | 526.27 | 490.36 | 523.19 | 455.34 | 1.08 (0.63, 1.85) | 0.90 (0.63, 1.28) | 0.94 (0.70, 1.27) | |
50–59 | 387.17 | 247.13 | 399.08 | 358.47 | 395.08 | 320.48 | 1.38 (0.82, 2.31) | 0.95 (0.69, 1.32) | 1.06 (0.81, 1.40) | |
60–69 | 354.97 | 107.65 | 413.55 | 203.48 | 391.99 | 168.05 | 2.42 (1.12, 5.25) | 1.81 (1.14, 2.86) | 1.97 (1.33, 2.91) | |
≥70 | 304.73 | 240.80 | 270.23 | 238.58 | 282.70 | 239.35 | 0.93 (0.45, 1.92) | 0.99 (0.57, 1.70) | 0.96 (0.62, 1.49) | |
Overall | 426.42 | 247.82 | 437.87 | 333.77 | 433.96 | 304.30 | 1.44 (1.09, 1.89) | 1.17 (0.98, 1.40) | 1.25 (1.07, 1.45) | |
Influenza complications – no DMARDs or biologics a | 18–29 | 76.49 | 0 | 0 | 0 | 25.21 | 0 | 0 | – | – |
30–39 | 60.73 | 0 | 77.64 | 0 | 72.59 | 0 | 0 | – | – | |
40–49 | 41.40 | 33.17 | 79.96 | 32.39 | 67.40 | 32.64 | 0.46 (0.06, 3.44) | 1.45 (0.43, 4.93) | 1.10 (0.39, 3.07) | |
50–59 | 65.34 | 19.66 | 57.68 | 20.35 | 60.25 | 20.11 | 1.39 (0.26, 7.46) | 1.98 (0.62, 6.27) | 1.77 (0.69, 4.56) | |
60–69 | 68.26 | 35.82 | 72.71 | 13.98 | 71.07 | 22.04 | 1.02 (0.23, 4.55) | 3.56 (0.76, 16.66) | 2.13 (0.76, 6.01) | |
≥70 | 145.29 | 80.04 | 112.16 | 42.47 | 124.13 | 55.49 | 0.99 (0.30, 3.28) | 1.83 (0.62, 5.35) | 1.40 (0.63, 3.08) | |
Overall | 76.64 | 34.43 | 74.20 | 22.41 | 75.03 | 26.53 | 1.23 (0.59, 2.51) | 2.23 (1.23, 4.03) | 1.76 (1.12, 2.77) | |
Pneumonia complications b | <65 | 49.38 | 31.92 | 90.34 | 34.93 | 76.75 | 33.91 | 1.00 (0.40, 2.45) | 2.20 (1.26, 3.85) | 1.78 (1.11, 2.85) |
≥65 | 134.89 | 29.83 | 141.59 | 47.02 | 139.25 | 41.10 | 1.66 (0.44, 6.26) | 2.12 (0.96, 4.68) | 2.01 (1.02, 3.95) | |
Overall | 76.22 | 31.33 | 105.54 | 38.34 | 95.66 | 35.95 | 1.15 (0.55, 2.41) | 2.15 (1.36, 3.38) | 1.84 (1.25, 2.70) | |
Stroke/MI complications c | <65 | 52.46 | 11.97 | 32.09 | 18.48 | 38.83 | 16.27 | 3.03 (0.85, 10.83) | 1.27 (0.56, 2.90) | 1.72 (0.87, 3.40) |
≥65 | 87.68 | 19.90 | 101.67 | 47.03 | 96.78 | 37.68 | 2.11 (0.42, 10.50) | 1.55 (0.68, 3.50) | 1.68 (0.82, 3.47) | |
Overall | 63.52 | 14.24 | 52.70 | 26.53 | 56.34 | 22.34 | 2.69 (1.0, 7.28) | 1.37 (0.77, 2.44) | 1.69 (1.02, 2.75) |