| | |
Incidence rates (per 100,000 patient-years) of influenza
|
Incidence rate ratios adjusted for baseline characteristics (95% CI)
|
|---|
|
Parameter
|
Age categories
|
Males
|
Females
|
Total
|
Males
|
Females
|
Total
|
|---|
| | |
RA cases
|
Controls
|
RA cases
|
Controls
|
RA cases
|
Controls
| | | |
|---|
|
Influenza
|
18–29
|
495.81
|
336.70
|
534.54
|
444.42
|
522.13
|
409.48
|
1.72 (0.50, 5.94)
|
1.54 (0.70, 3.38)
|
1.57 (0.81, 3.03)
|
| |
30–39
|
761.26
|
347.99
|
633.31
|
387.97
|
670.90
|
375.64
|
2.07 (0.97, 4.38)
|
1.54 (0.93, 2.54)
|
1.65 (1.09, 2.51)
|
| |
40–49
|
521.10
|
379.23
|
515.93
|
498.87
|
517.57
|
459.64
|
1.06 (0.62, 1.82)
|
0.88 (0.62, 1.24)
|
0.92 (0.69, 1.24)
|
| |
50–59
|
358.50
|
245.10
|
381.06
|
357.66
|
373.58
|
319.45
|
1.38 (0.83, 2.32)
|
0.94 (0.68, 1.30)
|
1.06 (0.80, 1.38)
|
| |
60–69
|
299.32
|
106.51
|
366.56
|
200.68
|
342.11
|
165.94
|
2.44 (1.13, 5.26)
|
1.75 (1.11, 2.76)
|
1.94 (1.31, 2.86)
|
| |
≥70
|
309.20
|
238.81
|
314.97
|
252.78
|
312.93
|
247.95
|
0.97 (0.48, 1.96)
|
0.97 (0.58, 1.62)
|
0.98 (0.64, 1.48)
|
| |
Overall
|
393.91
|
245.31
|
417.18
|
337.69
|
409.33
|
306.12
|
1.43 (1.09, 1.88)
|
1.13 (0.95, 1.35)
|
1.22 (1.05, 1.41)
|
|
Influenza complications
a
|
18–29
|
70.05
|
0
|
0
|
0
|
22.45
|
0
|
–
|
–
|
–
|
| |
30–39
|
57.49
|
0
|
71.98
|
0
|
67.71
|
0
|
–
|
–
|
–
|
| |
40–49
|
38.61
|
32.78
|
71.96
|
31.89
|
61.36
|
32.18
|
0.45 (0.06, 3.44)
|
1.45 (0.43, 4.93)
|
1.10 (0.39, 3.07)
|
| |
50–59
|
59.28
|
19.50
|
55.02
|
20.01
|
56.43
|
19.84
|
1.39 (0.26, 7.46)
|
2.06 (0.65, 6.47)
|
1.83 (0.71, 4.69)
|
| |
60–69
|
59.53
|
35.44
|
63.02
|
13.79
|
61.76
|
21.77
|
1.08 (0.25, 4.70)
|
3.17 (0.67, 14.97)
|
2.15 (0.77, 6.0)
|
| |
≥70
|
180.81
|
79.38
|
122.12
|
50.39
|
142.86
|
60.42
|
1.18 (0.39, 3.63)
|
1.76 (0.65, 4.74)
|
1.50 (0.71, 3.14)
|
| |
Overall
|
80.28
|
34.08
|
71.95
|
23.55
|
74.76
|
27.15
|
1.30 (0.64, 2.63)
|
2.17 (1.22, 3.86)
|
1.82 (1.16, 2.81)
|
|
Influenza – no DMARDs or biologics
|
18–29
|
541.94
|
343.41
|
609.33
|
456.87
|
587.11
|
419.88
|
1.72 (0.50, 5.49)
|
1.54 (0.71, 3.38)
|
1.57 (0.81, 3.04)
|
| |
30–39
|
804.93
|
352.17
|
670.75
|
377.68
|
710.76
|
369.80
|
2.07 (0.97, 4.38)
|
1.61 (0.97, 2.68)
|
1.71 (1.12, 2.61)
|
| |
40–49
|
516.81
|
383.82
|
526.27
|
490.36
|
523.19
|
455.34
|
1.08 (0.63, 1.85)
|
0.90 (0.63, 1.28)
|
0.94 (0.70, 1.27)
|
| |
50–59
|
387.17
|
247.13
|
399.08
|
358.47
|
395.08
|
320.48
|
1.38 (0.82, 2.31)
|
0.95 (0.69, 1.32)
|
1.06 (0.81, 1.40)
|
| |
60–69
|
354.97
|
107.65
|
413.55
|
203.48
|
391.99
|
168.05
|
2.42 (1.12, 5.25)
|
1.81 (1.14, 2.86)
|
1.97 (1.33, 2.91)
|
| |
≥70
|
304.73
|
240.80
|
270.23
|
238.58
|
282.70
|
239.35
|
0.93 (0.45, 1.92)
|
0.99 (0.57, 1.70)
|
0.96 (0.62, 1.49)
|
| |
Overall
|
426.42
|
247.82
|
437.87
|
333.77
|
433.96
|
304.30
|
1.44 (1.09, 1.89)
|
1.17 (0.98, 1.40)
|
1.25 (1.07, 1.45)
|
|
Influenza complications – no DMARDs or biologics
a
|
18–29
|
76.49
|
0
|
0
|
0
|
25.21
|
0
|
0
|
–
|
–
|
| |
30–39
|
60.73
|
0
|
77.64
|
0
|
72.59
|
0
|
0
|
–
|
–
|
| |
40–49
|
41.40
|
33.17
|
79.96
|
32.39
|
67.40
|
32.64
|
0.46 (0.06, 3.44)
|
1.45 (0.43, 4.93)
|
1.10 (0.39, 3.07)
|
| |
50–59
|
65.34
|
19.66
|
57.68
|
20.35
|
60.25
|
20.11
|
1.39 (0.26, 7.46)
|
1.98 (0.62, 6.27)
|
1.77 (0.69, 4.56)
|
| |
60–69
|
68.26
|
35.82
|
72.71
|
13.98
|
71.07
|
22.04
|
1.02 (0.23, 4.55)
|
3.56 (0.76, 16.66)
|
2.13 (0.76, 6.01)
|
| |
≥70
|
145.29
|
80.04
|
112.16
|
42.47
|
124.13
|
55.49
|
0.99 (0.30, 3.28)
|
1.83 (0.62, 5.35)
|
1.40 (0.63, 3.08)
|
| |
Overall
|
76.64
|
34.43
|
74.20
|
22.41
|
75.03
|
26.53
|
1.23 (0.59, 2.51)
|
2.23 (1.23, 4.03)
|
1.76 (1.12, 2.77)
|
|
Pneumonia complications
b
|
<65
|
49.38
|
31.92
|
90.34
|
34.93
|
76.75
|
33.91
|
1.00 (0.40, 2.45)
|
2.20 (1.26, 3.85)
|
1.78 (1.11, 2.85)
|
| |
≥65
|
134.89
|
29.83
|
141.59
|
47.02
|
139.25
|
41.10
|
1.66 (0.44, 6.26)
|
2.12 (0.96, 4.68)
|
2.01 (1.02, 3.95)
|
| |
Overall
|
76.22
|
31.33
|
105.54
|
38.34
|
95.66
|
35.95
|
1.15 (0.55, 2.41)
|
2.15 (1.36, 3.38)
|
1.84 (1.25, 2.70)
|
|
Stroke/MI complications
c
|
<65
|
52.46
|
11.97
|
32.09
|
18.48
|
38.83
|
16.27
|
3.03 (0.85, 10.83)
|
1.27 (0.56, 2.90)
|
1.72 (0.87, 3.40)
|
| |
≥65
|
87.68
|
19.90
|
101.67
|
47.03
|
96.78
|
37.68
|
2.11 (0.42, 10.50)
|
1.55 (0.68, 3.50)
|
1.68 (0.82, 3.47)
|
| |
Overall
|
63.52
|
14.24
|
52.70
|
26.53
|
56.34
|
22.34
|
2.69 (1.0, 7.28)
|
1.37 (0.77, 2.44)
|
1.69 (1.02, 2.75)
|
- Note: aInfluenza complications = pneumonia diagnosis (ICD-9 codes 480.xx–486.xx); stroke or MI (ICD-9 codes 410.xx, 430, 431, 432.x, 433.xx, 434.xx, 435.xx, 436); or neurological disorder (ICD-9 codes 320.xx–359.xx); all on or up to 30 days after an influenza diagnosis; bICD-9 codes 480.xx–486.xx; cICD-9 codes 410.xx, 430, 431, 432.x, 433.xx, 434.xx, 435.xx, 436.
