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Table 2 Incidence rates (per 100,000 patient-years) of influenza and incidence rate ratios adjusted for baseline characteristics in patient subgroups

From: Rheumatoid arthritis and the incidence of influenza and influenza-related complications: a retrospective cohort study

  

Incidence rates (per 100,000 patient-years) of influenza

Incidence rate ratios adjusted for baseline characteristics (95% CI)

Parameter

Age categories

Males

Females

Total

Males

Females

Total

  

RA cases

Controls

RA cases

Controls

RA cases

Controls

   

Influenza

18–29

495.81

336.70

534.54

444.42

522.13

409.48

1.72 (0.50, 5.94)

1.54 (0.70, 3.38)

1.57 (0.81, 3.03)

 

30–39

761.26

347.99

633.31

387.97

670.90

375.64

2.07 (0.97, 4.38)

1.54 (0.93, 2.54)

1.65 (1.09, 2.51)

 

40–49

521.10

379.23

515.93

498.87

517.57

459.64

1.06 (0.62, 1.82)

0.88 (0.62, 1.24)

0.92 (0.69, 1.24)

 

50–59

358.50

245.10

381.06

357.66

373.58

319.45

1.38 (0.83, 2.32)

0.94 (0.68, 1.30)

1.06 (0.80, 1.38)

 

60–69

299.32

106.51

366.56

200.68

342.11

165.94

2.44 (1.13, 5.26)

1.75 (1.11, 2.76)

1.94 (1.31, 2.86)

 

≥70

309.20

238.81

314.97

252.78

312.93

247.95

0.97 (0.48, 1.96)

0.97 (0.58, 1.62)

0.98 (0.64, 1.48)

 

Overall

393.91

245.31

417.18

337.69

409.33

306.12

1.43 (1.09, 1.88)

1.13 (0.95, 1.35)

1.22 (1.05, 1.41)

Influenza complications a

18–29

70.05

0

0

0

22.45

0

 

30–39

57.49

0

71.98

0

67.71

0

 

40–49

38.61

32.78

71.96

31.89

61.36

32.18

0.45 (0.06, 3.44)

1.45 (0.43, 4.93)

1.10 (0.39, 3.07)

 

50–59

59.28

19.50

55.02

20.01

56.43

19.84

1.39 (0.26, 7.46)

2.06 (0.65, 6.47)

1.83 (0.71, 4.69)

 

60–69

59.53

35.44

63.02

13.79

61.76

21.77

1.08 (0.25, 4.70)

3.17 (0.67, 14.97)

2.15 (0.77, 6.0)

 

≥70

180.81

79.38

122.12

50.39

142.86

60.42

1.18 (0.39, 3.63)

1.76 (0.65, 4.74)

1.50 (0.71, 3.14)

 

Overall

80.28

34.08

71.95

23.55

74.76

27.15

1.30 (0.64, 2.63)

2.17 (1.22, 3.86)

1.82 (1.16, 2.81)

Influenza – no DMARDs or biologics

18–29

541.94

343.41

609.33

456.87

587.11

419.88

1.72 (0.50, 5.49)

1.54 (0.71, 3.38)

1.57 (0.81, 3.04)

 

30–39

804.93

352.17

670.75

377.68

710.76

369.80

2.07 (0.97, 4.38)

1.61 (0.97, 2.68)

1.71 (1.12, 2.61)

 

40–49

516.81

383.82

526.27

490.36

523.19

455.34

1.08 (0.63, 1.85)

0.90 (0.63, 1.28)

0.94 (0.70, 1.27)

 

50–59

387.17

247.13

399.08

358.47

395.08

320.48

1.38 (0.82, 2.31)

0.95 (0.69, 1.32)

1.06 (0.81, 1.40)

 

60–69

354.97

107.65

413.55

203.48

391.99

168.05

2.42 (1.12, 5.25)

1.81 (1.14, 2.86)

1.97 (1.33, 2.91)

 

≥70

304.73

240.80

270.23

238.58

282.70

239.35

0.93 (0.45, 1.92)

0.99 (0.57, 1.70)

0.96 (0.62, 1.49)

 

Overall

426.42

247.82

437.87

333.77

433.96

304.30

1.44 (1.09, 1.89)

1.17 (0.98, 1.40)

1.25 (1.07, 1.45)

Influenza complications – no DMARDs or biologics a

18–29

76.49

0

0

0

25.21

0

0

 

30–39

60.73

0

77.64

0

72.59

0

0

 

40–49

41.40

33.17

79.96

32.39

67.40

32.64

0.46 (0.06, 3.44)

1.45 (0.43, 4.93)

1.10 (0.39, 3.07)

 

50–59

65.34

19.66

57.68

20.35

60.25

20.11

1.39 (0.26, 7.46)

1.98 (0.62, 6.27)

1.77 (0.69, 4.56)

 

60–69

68.26

35.82

72.71

13.98

71.07

22.04

1.02 (0.23, 4.55)

3.56 (0.76, 16.66)

2.13 (0.76, 6.01)

 

≥70

145.29

80.04

112.16

42.47

124.13

55.49

0.99 (0.30, 3.28)

1.83 (0.62, 5.35)

1.40 (0.63, 3.08)

 

Overall

76.64

34.43

74.20

22.41

75.03

26.53

1.23 (0.59, 2.51)

2.23 (1.23, 4.03)

1.76 (1.12, 2.77)

Pneumonia complications b

<65

49.38

31.92

90.34

34.93

76.75

33.91

1.00 (0.40, 2.45)

2.20 (1.26, 3.85)

1.78 (1.11, 2.85)

 

≥65

134.89

29.83

141.59

47.02

139.25

41.10

1.66 (0.44, 6.26)

2.12 (0.96, 4.68)

2.01 (1.02, 3.95)

 

Overall

76.22

31.33

105.54

38.34

95.66

35.95

1.15 (0.55, 2.41)

2.15 (1.36, 3.38)

1.84 (1.25, 2.70)

Stroke/MI complications c

<65

52.46

11.97

32.09

18.48

38.83

16.27

3.03 (0.85, 10.83)

1.27 (0.56, 2.90)

1.72 (0.87, 3.40)

 

≥65

87.68

19.90

101.67

47.03

96.78

37.68

2.11 (0.42, 10.50)

1.55 (0.68, 3.50)

1.68 (0.82, 3.47)

 

Overall

63.52

14.24

52.70

26.53

56.34

22.34

2.69 (1.0, 7.28)

1.37 (0.77, 2.44)

1.69 (1.02, 2.75)

  1. Note: aInfluenza complications = pneumonia diagnosis (ICD-9 codes 480.xx–486.xx); stroke or MI (ICD-9 codes 410.xx, 430, 431, 432.x, 433.xx, 434.xx, 435.xx, 436); or neurological disorder (ICD-9 codes 320.xx–359.xx); all on or up to 30 days after an influenza diagnosis; bICD-9 codes 480.xx–486.xx; cICD-9 codes 410.xx, 430, 431, 432.x, 433.xx, 434.xx, 435.xx, 436.