Skip to main content

Advertisement

Table 2 Lipid profile, disease activity, dyslipidaemia risk factors, and vascular measurements across the three visits for patients starting anti-TNFα therapy.

From: Anti-TNFα therapy transiently improves high density lipoprotein cholesterol levels and microvascular endothelial function in patients with rheumatoid arthritis: a Pilot Study

  Baseline 2 weeks 3 months P-value
Lipid Profile
 TC (mmol/l) 4.7 ± 1.0 4.9 ± 1.1 4.8 ± 0.9 0.170
 HDL cholesterol (mmol/l) 1.4 ± 0.3 1.5 ± 0.3 1.4 ± 0.3 0.014
 TG (mmol/l) 1.4 ± 0.6 1.5 ± 0.7 1.6 ± 0.9 0.236
Disease Activity
 CRP (mg/l) 10 (4 to 14) 3 (2.9 to 6) 5 (2.9 to 10) <0.001
 ESR (mmhr) 16 (9–34) 10 (5–21) 17 (5–27) 0.003
 Fibrinogen (g/l) 5.1 ± 1.0 4.2 ± .75 4.3 ± .91 <0.001
 DAS 28 4.22 ± 0.94 2.71 ± 1.38 2.80 ± 1.30 <0.001
 HAQ 2.1 ± 0.5 1.3 ± 0.9 1.3 ± 0.9 <0.001
 TNFα cytokine (pg/ml)* 3.27 (0–65) 16.2 (0–73) 33.1 (0–68) 0.452
Dyslipidaemia Risk Factors
 BMI (kg/m2) 30.2 ± 6.1 30.3 ± 6.1 30.3 ± 6.2 0.747
 IPAQ (met min/wk) 2850 ± 5451 2914 ± 3551 2503 ± 3163 0.625
Vascular Measurements
Microvascular endothelial-dependent and endothelial-independent function
 ACh (%) 319 ± 217 437 ± 247 348 ± 209 0.017
 SNP (%) 252 ± 126 288 ± 150 261 ± 152 0.314
Macrovascular endothelial-dependent and endothelial-independent function
 FMD (%) 9.4 ± 6.9 12.0 ± 9.6 12.0 ± 8.1 0.214
 GTN (%) 22.6 ± 7.5 23.2 ± 7.0 23.8 ± 7.2 0.737
  1. Results expressed as mean ± SD or median (interquartile range) as appropriate.
  2. TC: total cholesterol, HDL: high density lipoprotein, TG: triglycerides, CRP: C-reactive protein, ESR: erythrocyte sedimentation rate, DAS28: disease activity score, HAQ: health assessment questionnaire, TNFα: tumor necrosis factor alpha, BMI: body mass index, IPAQ: international physical activity questionnaire, ACh: acetylcholine-mediated dilatation, SNP: sodium nitroprusside-mediated dilatation, FMD: flow-mediated-dilatation, GTN: glyceryl trinitrate-mediated dilatation. p < 0.05 when compared to baseline visit. *Data for 21 patients only.