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Figure 2 | BMC Musculoskeletal Disorders

Figure 2

From: Selected statins produce rapid spinal motor neuron loss in vitro

Figure 2

Effect of statin exposure on neurite outgrowth. Fluvastatin exposure for 96 h resulted in a marked degeneration of neurites growing out from organotypic spinal cord cultures, when plated on collagen coated membranes. Cultures were stained with SMI32 antibodies developed with FITC-conjugated secondary antibody as described in the text. Vigorous outgrowth of ventral horn neurites is apparent in panel A, montage view (bar equals 1 mm) and panel B, detail view (bar equals 500 μm). Neuritic degeneration is seen in panel C (bar equals 500 μm).

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