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Figure 2 | BMC Musculoskeletal Disorders

Figure 2

From: Simvastatin suppresses dexamethasone-induced secretion of plasminogen activator inhibitor-1 in human bone marrow adipocytes

Figure 2

Time-course study of PAI-1 mRNA expression with dexamethasone or simvastatin. Human bone marrow adipocytes were cultured in serum-free DMEM with 1 μM dexamethasone (A) or 10 μM simvastatin (B). Total RNA was extracted from the floating adipocyte layer and PAI-1 mRNA were detected by real-time RT-PCR at 6, 12, 24, 36 and 48 h. PAI-1 mRNA expression was significantly up-regulated by dexamethasone at 12 h. PAI-1 mRNA expression was gradually down-regulated by simvastatin. Data represent relative expression levels vs. control levels at identical time points and are expressed as means ± SD. *P < 0.05 vs. untreated control cells at identical time points.

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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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