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Figure 1 | BMC Musculoskeletal Disorders

Figure 1

From: Simvastatin suppresses dexamethasone-induced secretion of plasminogen activator inhibitor-1 in human bone marrow adipocytes

Figure 1

Effects of dexamethasone and simvastatin on PAI-1 (A) and adiponectin (B) mRNA expression. Human bone marrow adipocytes were cultured in serum-free DMEM with 1 μM dexamethasone or 10 μM simvastatin for 24 h. PAI-1 and adiponectin mRNAs extracted from the floating adipocyte layer were assessed by real-time RT-PCR. Cont.: control group; DEX: dexamethasone-treated group; SIM: simvastatin-treated group. PAI-1 mRNA expression was up-regulated by dexamethasone and down-regulated by simvastatin. Data represent relative expression levels vs. control levels and are expressed as means ± SD. *P < 0.05 between two values.

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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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