Longitudinal ambulatory measurements of gait abnormality in dystrophin-deficient dogs

Table 2 Main results of the statistical analyses.

		Speed (m/s)	Speed/HW (/s)	SL (m)	SL/HW	SF (/s)	TP (W/kg)	Force (N/kg)	CCP/TP (%)	DVP/TP (%)	MLP/TP (%)	Regularity	Distance
Age effect	Healthy	p < 0.0001 (↗)	p = 0.0024 (↘)	p < 0.0001 (↗)	NS	p < 0.0001 (↘)	NS	NS	NS	NS	p = 0.0089 (↘)	p = 0.0145 (↗)	p = 0.0068 (↘)
	GRMD	NS	p = 0.0067 (↘)	NS	NS	p = 0.0350 (↘)	NS	p = 0.0034 (↘)	NS	NS	NS	NS	NS
	Group effect	p < 0.0001	p = 0.0003	p = 0.0002	p = 0.0002	NS	p < 0.0001	p = 0.0006	NS	p = 0.0427	p = 0.0162	p = 0.0090	p < 0.0001
2 months	Healthy	1.77 (0.29)	5.68 (0.90)	0.61 (0.07)	1.97 (0.26)	2.89 (0.20)	81.5 (18.6)	53.2 (6.3)	44.0 (7.7)	40.3 (7.5)	15.8 (6.1)	197 (49)	1.14 (0.60)
	GRMD	1.02 (0.24)	3.72 (1.04)	0.37 (0.09)	1.35 (0.27)	2.70 (0.70)	44.1 (19.2)	43.4 (20.7)	45.7 (9.9)	34.7 (10.7)	11.2 (13.1)	209 (56)	2.61 (0.73)
	p	p = 0.0010	p = 0.0054	p < 0.0001	p = 0.0001	NS	p = 0.0017	NS	NS	NS	NS	NS	p = 0.0031
9 months	Healthy	2.61 (0.18)	4.39 (0.26)	1.18 (0.03)	1.99 (0.06)	2.21 (0.14)	111.4 (16.3)	41.7 (2.6)	47.8 (4.8)	43.3 (3.9)	8.9 (3.5)	269 (44)	0.80 (0.24)
	GRMD	0.88 (0.46)	1.66 (0.75)	0.49 (0.22)	0.92 (0.31)	1.77 (0.43)	20.8 (16.9)	20.4 (9.3)	44.7 (13.5)	29.4 (6.6)	23.8 (9.1)	225 (31)	3.7 (0.93)
	p	p < 0.0001	p < 0.0001	p < 0.0001	p < 0.0001	p = 0.0337	p < 0.0001	p = 0.0002	NS	p = 0.0009	p = 0.0033	NS	p < 0.0001
Correlation with motor score		-0.4353	-0.6480		-0.6834	-0.5082	-0.5640	-0.5368	-0.3492		0.4454		0.6248
	p	p = 0.0002	p < 0.0001	NS	p < 0.0001	p < 0.0001	p < 0.0001	p < 0.0001	p = 0.0030	NS	p = 0.0001	NS	p < 0.0001

For each variable, the age effect for each group is presented in the first row, as well as the group effect. The two following rows show the mean (SD) of healthy dogs/the mean (SD) of GRMD dogs, just above the p value, for the two extreme age points (i.e. 2 and 9 months). The Pearson's coefficient of correlation with the motor score and associated p values are given in the last row. The data at each age point are given in Additional file 2 available online.
Abbreviations: HW: height at withers, SL: stride length, SF: stride frequency, TP: total power, CCP/TP: cranio-caudal part of the total power, DVP/TP; dorso-ventral part of the total power, MLP/TP: medio-lateral part of the total power, Distance (PCA): distance from the centre of gravity of the healthy group on the principal analysis component plane, NS: not significant.

ISSN: 1471-2474