Demographics | Patients (n = 31) | Controls (n = 35) | P-value |
---|---|---|---|
Age (years) | 66.5 (11.6) | 66.2 (10.1) | 0.916 |
Height (cm) | 175.3 (9.7) | 176.2 (5.2) | 0.666 |
Weight (kg) | 77.3 (14.5) | 84.7 (10.7) | 0.020 |
Education > 13 years | 8 (32.0) | 18 (51.4) | 0.188 |
Living alone | 12 (38.7) | 3 (8.6) | 0.007 |
Current smoker | 10 (33.3) | 8 (22.9) | 0.411 |
Alcohol abuse | 0 (0.0) | 0 (0.0) | - |
Clinical characteristics | |||
Rheumatoid arthritis | 1 (3.2) | 0 (0.0) | 0.470 |
Inflammatory diseases | 1 (3.2) | 1 (2.9) | 1.000 |
Endocrine diseases° | 1 (3.2) | 1 (2.9) | 1.000 |
Cardiovascular diseases^ | 4 (12.9) | 7 (20.0) | 0.521 |
Diabetes | 1 (3.2) | 1 (2.9) | 1.000 |
Glucocorticoids | |||
Ever | 3 (11.5) | 2 (5.9) | 0.644 |
Current | 2 (7.7) | 0 (0.0) | 0.184 |
≥ 3 months | 2 (6.5) | 2 (5.7) | 1.000 |
Calcium supplement | 3 (9.7) | 3 (8.6) | 1.000 |
Vitamin-D supplement | 12 (38.7) | 14 (40.0) | 1.000 |
Bisphosphonate | 2 (6.4) | 1 (2.9) | 0.597 |
Loss of height (≥ 3 cm)• | 6 (21.4) | 6 (17.6) | 0.755 |
Previous fracture† | 4 (12.9) | 4 (12.9) | 1.000 |
History of hip fracture in a parent | 3 (10.3) | 3 (9.1) | 1.000 |
Falls (≥ 1 fall last year) | 9 (40.9) | 5 (18.5) | 0.116 |
Bone mineral density | |||
BMD femoral neck (g/cm2) | 0.78 (0.14) | 0.92 (0.14) | <0.001 |
BMD total hip (g/cm2) | 0.84 (0.16) | 1.01 (0.13) | <0.001 |
BMD L2-4 (g/cm2) | 1.08 (0.24) | 1.27 (0.20) | 0.001 |
T-score femoral neck (SD) | -2.24 (1.05) | -1.15 (1.11) | <0.001 |
T-score total hip (SD) | -1.65 (1.04) | -0.64 (0.91) | <0.001 |
T-score L2-4 (SD) | -1.26 (2.05) | 0.25 (1.69) | 0.002 |
Femoral neck | 0.006** | ||
Normal BMD | 2 (6.9) | 14 (40.0) | |
Osteopenia | 20 (69.0) | 18 (51.4) | |
Osteoporosis | 7 (24.1) | 3 (8.6) | |
Total hip | <0.001** | ||
Normal BMD | 6 (23.1) | 23 (65.7) | |
Osteopenia | 15 (57.7) | 12 (34.3) | |
Osteoporosis | 7 (19.2) | 0 (0.0) | |
Lumbar spine L2-4 | 0.002** | ||
Normal BMD | 11 (35.5) | 26 (74.3) | |
Osteopenia | 12 (38.7) | 8 (22.9) | |
Osteoporosis | 8 (25.8) | 1 (2.9) | |
Normal BMD at all sites* | 2 (6.5) | 14 (40.0) | 0.002 |
Osteopenia at ≥1 site but no osteoporosis* | 20 (64.5) | 17 (48.6) | 0.222 |
Osteoporosis at ≥1 site* | 9 (29.0) | 5 (11.4) | 0.120 |