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Table 2 Baseline levels of cytokines and heat shock proteins

From: Effects on muscle performance of NSAID treatment with Piroxicam versus placebo in geriatric patients with acute infection-induced inflammation. a double blind randomized controlled trial

 

sensitivity

Placebo N = 14

Piroxicam N = 14

Cytokines in pg/mL

   

IL-1beta

< 15

31.0 (21.0-112.5)

14.9 (14.9-65.3)

IL-1RA

< 20

245.0 (134.5-537.0)

412.0 (177.5-615.0)

IL-2

< 15

14.9 (14.9-35.0)

14.9 (14.9-14.9)

IL-2R

< 40

248.0 (150.5-346.5)

427.5 (207.5-595.0)

IL-4

< 5

4.9 (4.9-22.5)

4.9 (4.9-10.5)

IL-5

< 5

LO

LO

IL-6

< 5

22.0 (14.5-89.5)

19.0 (6.5-160.5)

IL-7

< 25

24.9 (24.9-32.5)

24.9 (24.9-40.5)

IL-10

< 3

5.0 (3.0-29.0)

5.0 (3.0-6.0)

IL-12

< 6

169.0 (107.0-253.0)

160.0 (115.0-274.3)

IL-13

< 6

LO

LO

IL-15

< 25

39.0 (24.9-134.5)

25.0 (24.9-60.0)

IL-17

< 20

LO

LO

GM-CSF

< 5

4.9 (4.9-44.0)

4.9 (4.9-8.0)

TNF-alpha

< 5

4.9 (4.9-9.5)

4.9 (4.9-8.5)

IFN-alpha

< 25

38.0 (25.5-66.5)

41.5 (24.9-55.3)

IFN-gamma

< 2

LO

LO

MCP-1/CCL2

< 8

778.0 (561.0-1228.5)

818.0 (458.5-1017.0)

MIP-1alpha/CCL3

< 15

44.0 (21.5-96.5)

49.0 (30.0-66.5)

MIP-1beta/CCL4

< 10

123.0 (62.0-186.0)

106.0 (56.0-192.0)

RANTES/CCL5

< 20

HI

HI

Eotaxin/CCL11

< 5

76.0 (64.5-155.5)

79.0 (63.8-127.5)

IL-8/CXCL8

< 3

132.0 (60.0-294.5)

63.0 (53.5-276.0)

MIG/CXCL9

< 20

76.0 (61.0-186.0)

133.0 (82.0-180.5)

IP-10/CXCL10

< 5

44.0 (32.0-65.0)

53.0 (46.0-106.0)

Serum Hsp, ng/mL

   

- Hsp27

< 0.39

48.9 (14.3-72.3)

20.1 (15.8-53.5)

- Hsp70

< 0.09

1.1 (0.6-1.7)

1.5 (0.9-1.7)

Intracellular Hsp, MFI (flow cytometry)

   

- Hsp27

   

Lymphocytes - WHC

 

2.4 (1.6-4.3)

2.4 (1.5-4.9)

- 42°C (HC)

 

5.2 (3.4-7.6)

5.0 (4.1-6.5)

Monocytes - WHC

 

28.1 (25.3-42.9)

29.0 (16.0-43.1)

- 42°C (HC)

 

40.3 (29.2-51.2)

41.2 (29.8-59.9)

- Hsp70

   

Lymphocytes - WHC

 

2.1 (1.6-4.4)

2.5 (1.5-4.3)

- 42°C (HC)

 

11.9 (7.8-14.9)

13.5 (5.1-18.0)

Monocytes - WHC

 

13.5 (8.2-26.8)

12.7 (8.1-18.8)

- 42°C (HC)

 

244.1 (149.9-332.1)

211.0 (160.5-343.4)

  1. Data represent median values (interquartile range). P-values refer to unpaired comparisons by Mann Whitney U test. No significant difference was observed for any of the parameters. GM-CSF = granulocyte macrophage colony-stimulating factor; IL = interleukin. IL-1RA = IL-1 receptor antagonist. TNF-alpha = tumor necrosis factor alpha. IFN = interferon. IL-2R = IL- 2 receptor. For chemokines old and new names are indicated, separated by a forward slash; MCP = monocyte chemoattractant protein. MIP = macrophage inflammatory protein. RANTES = Regulated upon Activation, Normal T-cell Expressed, and Secreted. MIG = monokine induced by interferon gamma. IP-10 = interferon γ-inducible protein 10. Hsp = heat shock protein(s), MFI = Mean Fluorescence Intensity, WHC = without heat challenge, 42°C(HC) = heat challenge, LO = below lower detection limit, HI = above upper detection limit.
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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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