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Table 2 Baseline levels of cytokines and heat shock proteins

From: Effects on muscle performance of NSAID treatment with Piroxicam versus placebo in geriatric patients with acute infection-induced inflammation. a double blind randomized controlled trial

  sensitivity Placebo N = 14 Piroxicam N = 14
Cytokines in pg/mL    
IL-1beta < 15 31.0 (21.0-112.5) 14.9 (14.9-65.3)
IL-1RA < 20 245.0 (134.5-537.0) 412.0 (177.5-615.0)
IL-2 < 15 14.9 (14.9-35.0) 14.9 (14.9-14.9)
IL-2R < 40 248.0 (150.5-346.5) 427.5 (207.5-595.0)
IL-4 < 5 4.9 (4.9-22.5) 4.9 (4.9-10.5)
IL-5 < 5 LO LO
IL-6 < 5 22.0 (14.5-89.5) 19.0 (6.5-160.5)
IL-7 < 25 24.9 (24.9-32.5) 24.9 (24.9-40.5)
IL-10 < 3 5.0 (3.0-29.0) 5.0 (3.0-6.0)
IL-12 < 6 169.0 (107.0-253.0) 160.0 (115.0-274.3)
IL-13 < 6 LO LO
IL-15 < 25 39.0 (24.9-134.5) 25.0 (24.9-60.0)
IL-17 < 20 LO LO
GM-CSF < 5 4.9 (4.9-44.0) 4.9 (4.9-8.0)
TNF-alpha < 5 4.9 (4.9-9.5) 4.9 (4.9-8.5)
IFN-alpha < 25 38.0 (25.5-66.5) 41.5 (24.9-55.3)
IFN-gamma < 2 LO LO
MCP-1/CCL2 < 8 778.0 (561.0-1228.5) 818.0 (458.5-1017.0)
MIP-1alpha/CCL3 < 15 44.0 (21.5-96.5) 49.0 (30.0-66.5)
MIP-1beta/CCL4 < 10 123.0 (62.0-186.0) 106.0 (56.0-192.0)
RANTES/CCL5 < 20 HI HI
Eotaxin/CCL11 < 5 76.0 (64.5-155.5) 79.0 (63.8-127.5)
IL-8/CXCL8 < 3 132.0 (60.0-294.5) 63.0 (53.5-276.0)
MIG/CXCL9 < 20 76.0 (61.0-186.0) 133.0 (82.0-180.5)
IP-10/CXCL10 < 5 44.0 (32.0-65.0) 53.0 (46.0-106.0)
Serum Hsp, ng/mL    
- Hsp27 < 0.39 48.9 (14.3-72.3) 20.1 (15.8-53.5)
- Hsp70 < 0.09 1.1 (0.6-1.7) 1.5 (0.9-1.7)
Intracellular Hsp, MFI (flow cytometry)    
- Hsp27    
Lymphocytes - WHC   2.4 (1.6-4.3) 2.4 (1.5-4.9)
- 42°C (HC)   5.2 (3.4-7.6) 5.0 (4.1-6.5)
Monocytes - WHC   28.1 (25.3-42.9) 29.0 (16.0-43.1)
- 42°C (HC)   40.3 (29.2-51.2) 41.2 (29.8-59.9)
- Hsp70    
Lymphocytes - WHC   2.1 (1.6-4.4) 2.5 (1.5-4.3)
- 42°C (HC)   11.9 (7.8-14.9) 13.5 (5.1-18.0)
Monocytes - WHC   13.5 (8.2-26.8) 12.7 (8.1-18.8)
- 42°C (HC)   244.1 (149.9-332.1) 211.0 (160.5-343.4)
  1. Data represent median values (interquartile range). P-values refer to unpaired comparisons by Mann Whitney U test. No significant difference was observed for any of the parameters. GM-CSF = granulocyte macrophage colony-stimulating factor; IL = interleukin. IL-1RA = IL-1 receptor antagonist. TNF-alpha = tumor necrosis factor alpha. IFN = interferon. IL-2R = IL- 2 receptor. For chemokines old and new names are indicated, separated by a forward slash; MCP = monocyte chemoattractant protein. MIP = macrophage inflammatory protein. RANTES = Regulated upon Activation, Normal T-cell Expressed, and Secreted. MIG = monokine induced by interferon gamma. IP-10 = interferon γ-inducible protein 10. Hsp = heat shock protein(s), MFI = Mean Fluorescence Intensity, WHC = without heat challenge, 42°C(HC) = heat challenge, LO = below lower detection limit, HI = above upper detection limit.