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Table 4 Effects of daily 30 mg/kg dosing with the dopamine 1/5 receptor agonist SKF 81297 on atrophying skeletal muscle mass and force in wild-type (+/+ D5R) and dopamine 5 receptor homozygous knockout (-/- D5R) mice.

From: Activation of the dopamine 1 and dopamine 5 receptors increase skeletal muscle mass and force production under non-atrophying and atrophying conditions

Parameter Uncasted Vehicle +/+ D5R Casted Vehicle +/+ D5R Casted SKF 81297 +/+ D5R Uncasted Vehicle -/- D5R Casted Vehicle -/- D5R Casted SKF 81297 -/- D5R
# mice 12 12 12 12 12 12
Initial body mass (grams) 23.0 (0.5) 22.7 (0.3) 22.3 (0.6) 22.3 (0.3) 22.5 (0.4) 21.8 (0.4)
Final body mass (grams) 23.0 (0.4) 21.6# (0.4) 22.8* (0.7) 23.1 (0.4) 21.3# (0.5) 22.4#* (0.4)
EDL mass (milligrams) 8.8 (0.2) 6.0# (0.2) 6.6#* (0.3) 8.8 (0.2) 5.9# (0.2) 6.2# (0.2)
EDL Po (milliNewtons) 351.3 (10.8) 237.3# (8.0) 269.7#* (13.6) 348.4 (10.5) 233.1# (9.2) 256.0# (12.1)
Soleus mass (milligrams) 7.5 (0.2) 4.5# (0.2) 4.6# (0.2) 7.4 (0.2) 5.0# (0.2) 4.9# (0.2)
Soleus Po (milliNewtons) 202.2 (8.2) 120.7# (8.1) 130.0# (8.5) 204.2 (7.6) 132.8# (8.4) 129.9# (7.1)
  1. All data given as mean + (SEM). * - statistically significant (p < 0.05) versus casted vehicle; # - statistically significant (p < 0.05) versus uncasted vehicle.