Skip to main content

Table 4 Effects of daily 30 mg/kg dosing with the dopamine 1/5 receptor agonist SKF 81297 on atrophying skeletal muscle mass and force in wild-type (+/+ D5R) and dopamine 5 receptor homozygous knockout (-/- D5R) mice.

From: Activation of the dopamine 1 and dopamine 5 receptors increase skeletal muscle mass and force production under non-atrophying and atrophying conditions

Parameter Uncasted
Vehicle
+/+ D5R
Casted
Vehicle
+/+ D5R
Casted
SKF 81297
+/+ D5R
Uncasted
Vehicle
-/- D5R
Casted
Vehicle
-/- D5R
Casted
SKF 81297
-/- D5R
# mice 12 12 12 12 12 12
Initial body
mass (grams)
23.0
(0.5)
22.7
(0.3)
22.3
(0.6)
22.3
(0.3)
22.5
(0.4)
21.8
(0.4)
Final body
mass (grams)
23.0
(0.4)
21.6#
(0.4)
22.8*
(0.7)
23.1
(0.4)
21.3#
(0.5)
22.4#*
(0.4)
EDL mass
(milligrams)
8.8
(0.2)
6.0#
(0.2)
6.6#*
(0.3)
8.8
(0.2)
5.9#
(0.2)
6.2#
(0.2)
EDL Po
(milliNewtons)
351.3
(10.8)
237.3#
(8.0)
269.7#*
(13.6)
348.4
(10.5)
233.1#
(9.2)
256.0#
(12.1)
Soleus mass
(milligrams)
7.5
(0.2)
4.5#
(0.2)
4.6#
(0.2)
7.4
(0.2)
5.0#
(0.2)
4.9#
(0.2)
Soleus Po
(milliNewtons)
202.2
(8.2)
120.7#
(8.1)
130.0#
(8.5)
204.2
(7.6)
132.8#
(8.4)
129.9#
(7.1)
  1. All data given as mean + (SEM). * - statistically significant (p < 0.05) versus casted vehicle; # - statistically significant (p < 0.05) versus uncasted vehicle.