Table 4 Effects of daily 30 mg/kg dosing with the dopamine 1/5 receptor agonist SKF 81297 on atrophying skeletal muscle mass and force in wild-type (+/+ D5R) and dopamine 5 receptor homozygous knockout (-/- D5R) mice.
Parameter | Uncasted Vehicle +/+ D5R | Casted Vehicle +/+ D5R | Casted SKF 81297 +/+ D5R | Uncasted Vehicle -/- D5R | Casted Vehicle -/- D5R | Casted SKF 81297 -/- D5R |
|---|---|---|---|---|---|---|
# mice | 12 | 12 | 12 | 12 | 12 | 12 |
Initial body mass (grams) | 23.0 (0.5) | 22.7 (0.3) | 22.3 (0.6) | 22.3 (0.3) | 22.5 (0.4) | 21.8 (0.4) |
Final body mass (grams) | 23.0 (0.4) | 21.6# (0.4) | 22.8* (0.7) | 23.1 (0.4) | 21.3# (0.5) | 22.4#* (0.4) |
EDL mass (milligrams) | 8.8 (0.2) | 6.0# (0.2) | 6.6#* (0.3) | 8.8 (0.2) | 5.9# (0.2) | 6.2# (0.2) |
EDL Po (milliNewtons) | 351.3 (10.8) | 237.3# (8.0) | 269.7#* (13.6) | 348.4 (10.5) | 233.1# (9.2) | 256.0# (12.1) |
Soleus mass (milligrams) | 7.5 (0.2) | 4.5# (0.2) | 4.6# (0.2) | 7.4 (0.2) | 5.0# (0.2) | 4.9# (0.2) |
Soleus Po (milliNewtons) | 202.2 (8.2) | 120.7# (8.1) | 130.0# (8.5) | 204.2 (7.6) | 132.8# (8.4) | 129.9# (7.1) |