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Table 3 Effects of once daily 30 mg/kg treatment with the dopamine 1/5 receptor agonist SKF 81297 on atrophying skeletal muscle mass in wild-type (+/+ D1R) and dopamine 1 receptor homozygous knockout (-/- D1R) mice

From: Activation of the dopamine 1 and dopamine 5 receptors increase skeletal muscle mass and force production under non-atrophying and atrophying conditions

Parameter Uncasted Vehicle +/+ D1R Casted Vehicle +/+ D1R Casted SKF 81297 +/+ D1R Uncasted Vehicle -/- D1R Casted Vehicle -/- D1R Casted SKF 81297 -/- D1R
# mice 12 11 10 11 11 11
Initial body mass (grams) 24.6 (1.0) 24.4 (0.9) 24.1 (1.1) 22.1 (1.1) 22.3 (1.1) 21.6 (0.8)
Final body mass (grams) 24.9 (1.0) 24.2 (0.8) 25.8#* (1.2) 23.6 (1.1) 22.6# (1.1) 23.0# (0.9)
EDL mass (milligrams) 9.8 (0.4) 7.4# (0.4) 8.4#* (0.5) 9.6 (0.4) 7.5# (0.5) 7.4# (0.4)
EDL Po (milliNewtons) 402.8 (16.0) 315.0# (15.6) 359.5#* (22.7) 371.0 (11.0) 317.8# (22.1) 307.6# (16.3)
Soleus mass (milligrams) 7.6 (0.3) 5.0# (0.3) 5.6#* (0.4) 6.9 (0.3) 4.6# (0.3) 4.8# (0.3)
Soleus Po (milliNewtons) 209.3 (6.1) 149.0# (6.8) 164.2# (12.0) 196.2 (11.3) 119.7# (7.1) 121.4# (7.0)
  1. All data given as mean + (SEM). * - statistically significant (p < 0.05) versus casted vehicle; # - statistically significant (p < 0.05) versus uncasted vehicle.