Table 3 Effects of once daily 30 mg/kg treatment with the dopamine 1/5 receptor agonist SKF 81297 on atrophying skeletal muscle mass in wild-type (+/+ D1R) and dopamine 1 receptor homozygous knockout (-/- D1R) mice
Parameter | Uncasted Vehicle +/+ D1R | Casted Vehicle +/+ D1R | Casted SKF 81297 +/+ D1R | Uncasted Vehicle -/- D1R | Casted Vehicle -/- D1R | Casted SKF 81297 -/- D1R |
|---|---|---|---|---|---|---|
# mice | 12 | 11 | 10 | 11 | 11 | 11 |
Initial body mass (grams) | 24.6 (1.0) | 24.4 (0.9) | 24.1 (1.1) | 22.1 (1.1) | 22.3 (1.1) | 21.6 (0.8) |
Final body mass (grams) | 24.9 (1.0) | 24.2 (0.8) | 25.8#* (1.2) | 23.6 (1.1) | 22.6# (1.1) | 23.0# (0.9) |
EDL mass (milligrams) | 9.8 (0.4) | 7.4# (0.4) | 8.4#* (0.5) | 9.6 (0.4) | 7.5# (0.5) | 7.4# (0.4) |
EDL Po (milliNewtons) | 402.8 (16.0) | 315.0# (15.6) | 359.5#* (22.7) | 371.0 (11.0) | 317.8# (22.1) | 307.6# (16.3) |
Soleus mass (milligrams) | 7.6 (0.3) | 5.0# (0.3) | 5.6#* (0.4) | 6.9 (0.3) | 4.6# (0.3) | 4.8# (0.3) |
Soleus Po (milliNewtons) | 209.3 (6.1) | 149.0# (6.8) | 164.2# (12.0) | 196.2 (11.3) | 119.7# (7.1) | 121.4# (7.0) |