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Table 3 Demographics of the study population and serum levels of enzyme markers grouped by radiological severity (Kellgren/Lawrence Score) and distribution of the haplogroups H, U and J in the 3 radiographic groups

From: Mitochondrial DNA (mtDNA) haplogroups and serum levels of anti-oxidant enzymes in patients with osteoarthritis

  Healthy controls (n = 77) OA patients (n = 73)   
Mean age (range) 66.01 years-old (42-94) 67.74 years-old (51-95)   
Females/Males 39 females/38 males 52 females/21 males   
Haplogroups Group A (n = 77)
K/L grade 0 and I
Group B (n = 47)
K/L grade II and III
Group C (n = 24)
K/L grade IV
  
Haplogroup H, n(%) 25 (32.5) 18 (38.3) 7 (29.2)   
Haplogroup U, n(%) 25 (32.5) 12 (25.5) 13 (54.2)   
Haplogroup J, n(%) 27 (35) 17 (36.2) 4 (16.7)   
Markers Mean (SD) Median Mean (SD) Median Mean (SD) Median J-T p*
SOD2 (ng/mL) 20.83 (30.81) 13.50 35.75 (10.44) 35.02 38.10 (12.74) 39.23 7.796 < 0.001**
Catalase (ng/mL) 14.50 (27.68) 5.03 22.82 (42.49) 8.56 20.58 (38.87) 8.00 1.227 0.220
  1. Group A: K/L grade 0 and I; Group B: K/L grade II and III; Group C: K/L grade IV
  2. (*) Jonckheere-Terstra (J-T) non-parametric test
  3. J-T = established J-T statistic
  4. (**) indicates statistical significance after Bonferroni correction (p ≤ 0.05)
  5. SD = Standard deviation