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Table 9 Results of meta-analysis.

From: Systematic review with meta-analysis: cytokines in fibromyalgia syndrome

Study FMS Controls Weight SMD
  Mean Std Total Mean Std Total   IV, Random, 95% CI
IL-1: plasma, ELISA or immunoassay
Togo 2009 0.79 0.64 7 1.24 1.17 9 16.4% -0.43 [-1.44, 0.57]
Feng 2009 74.5 116.5 100 45.6 53.1 35 41.3% 0.28 [-0.11, 0.66]
Bazzichi 2007 4.54 9.7 80 7.44 6.62 45 42.3% -0.33 [-0.70, 0.04]
Total (95% CI)    187    89 100.0% -0.10 [-0.58, 0.39]
Heterogeneity: Tau2 = 0.11; Chi2 = 5.52, df = 2 (P = 0.06); I2 = 64%
Test for overall effect: Z = 0.39 (P = 0.69)
IL-6: plasma, ELISA or immunoassay or bioplex assay
Togo 2009 14.0 10.9 7 16.8 15.3 9 9.6% -0.19 [-1.19, 0.80]
Schwarz 2002 1.01 0.47 17 1.45 2.17 17 20.7% -0.27 [-0.95, 0.40]
Bazzichi 2007 2.76 3.99 80 4.34 4.51 45 69.7% -0.38 [-0.74, -0.01]
Total (95% CI)    104    71 100.0% -0.34 [-0.64, -0.03]
Heterogeneity: Tau2 = 0.00; Chi2 = 0.15, df = 2 (P = 0.93); I2 = 0%
Test for overall effect: Z = 2.15 (P = 0.03)
IL-6: serum, ELISA or immunoassay or bioplex assay
Gür 2002 5.52 3.96 81 5.46 1.37 32 25.7% 0.02 [-0.39, 0.43]
Hernandez 2010 16.28 8.13 64 0.92 0.32 25 24.8% 2.20 [1.63, 2.77]
Wallace 2001 7.19 2.02 56 6.3 6.72 36 25.6% 0.20 [-0.22, 0.62]
Wang 2008 2.57 1.38 20 0.92 0.32 25 23.9% 1.71 [1.02, 2.40]
Total (95% CI)    221    118 100.0% 1.01 [-0.03, 2.05]
Heterogeneity: Tau2 = 1.05; Chi2 = 51.09, df = 3 (P < 0.00001); I2 = 94%
Test for overall effect: Z = 1.91 (P = 0.06)
IL-8: plasma, ELISA or immunoassay
Bazzichi 2007 61.89 149.0 80 7.9 17.5 45 41.2% 0.45 [0.08, 0.82]
Blanco 2010 83.0 253.0 79 84.0 253.0 59 42.8% -0.00 [-0.34, 0.33]
Togo 2009 8.4 1.9 7 11.8 5.4 9 16.0% -0.75 [-1.79, 0.28]
Total (95% CI)    166    113 100.0% 0.06 [-0.43, 0.56]
Heterogeneity: Tau2 = 0.12; Chi2 = 6.23, df = 2 (P = 0.04); I2 = 68%
Test for overall effect: Z = 0.25 (P = 0.80)
TNF: serum, ELISA or immunoassay or bioplex assay
Hernandez 2010 20.42 7.24 64 35.73 0.72 25 33.0% -2.46 [-3.05, -1.87]
Wang 2008 3.27 5.08 20 3.89 12.95 80 33.5% -0.05 [-0.54, 0.44]
Üçeyler 2006 7.41 11.01 26 6.7 9.5 40 33.5% 0.07 [-0.42, 0.56]
Total (95% CI)    110    145 100.0% -0.81 [-2.31, 0.70]
Heterogeneity: Tau2 = 1.70; Chi2 = 49.74, df = 2 (P < 0.00001); I2 = 96%
Test for overall effect: Z = 1.05 (P = 0.29)
TNF: plasma, ELISA or immunoassay
Bazzichi 2007 22.59 29.55 80 11.07 6.77 45 28.0% 0.48 [0.11, 0.85]
Blanco 2010 163.0 435.0 79 161.0 319.0 59 28.5% 0.01 [-0.33, 0.34]
Feng 2009 12.2 10.2 100 40.1 73.5 35 27.6% -0.73 [-1.12, -0.33]
Togo 2009 0.24 0.13 7 0.7 0.61 9 16.0% -0.93 [-1.98, 0.13]
Total (95% CI)    266    148 100.0% -0.21 [-0.82, 0.39]
Heterogeneity: Tau2 = 0.30; Chi2 = 21.71, df = 3 (P < 0.0001); I2 = 86%
Test for overall effect: Z = 0.69 (P = 0.49)
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