Table 8 Characteristics of studies investigating levels of cytokines in skin of FMS patients.
From: Systematic review with meta-analysis: cytokines in fibromyalgia syndrome
Author, yr. Diagnosis criteria | N patients/controls | a) Material b) Methods c) Investigated targets | Results | Modified CEBM level | NOS | W-MeQS |
|---|---|---|---|---|---|---|
Salemi, 2003 ACR | 53/10 | a) skin biopsy b) RT-PCR, IHC c) IL-1β, IL-6, TNF | Detectable cytokines in FMS: IL-1β (19/50) IL-6 (14/51) TNF (17/53) None of the cytokines could be detected in control skin. | 3d | 2 | 0.7 |
Blanco, 2010 ACR | 63/49 | a) skin b) IHC c) MCP-1, TNF | MCP-1: FMS < controls | 3c | 3 | 0.8 |