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Table 8 Characteristics of studies investigating levels of cytokines in skin of FMS patients.

From: Systematic review with meta-analysis: cytokines in fibromyalgia syndrome

Author, yr.
Diagnosis criteria
N patients/controls a) Material
b) Methods
c) Investigated targets
Results Modified CEBM
level
NOS W-MeQS
Salemi, 2003
ACR
53/10 a) skin biopsy
b) RT-PCR, IHC
c) IL-1β, IL-6, TNF
Detectable cytokines in FMS:
IL-1β (19/50)
IL-6 (14/51)
TNF (17/53)
None of the cytokines could be detected in control skin.
3d 2 0.7
Blanco, 2010
ACR
63/49 a) skin
b) IHC
c) MCP-1, TNF
MCP-1: FMS < controls 3c 3 0.8
  1. Abbreviations:
  2. ACR: American College of Rheumatology; CEMB: Center of Evidence Based Medicine; FMS: fibromyalgia syndrome; IHC: immunohistochemistry; IL: interleukin; NOS: Newcastle Ottawa Scale; RT-PCR: reverse transcriptions PCR; W-MeQS: Würzburg Methodological Quality Score; yr: year
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