Figure 1From: Gene expression profile of the cartilage tissue spontaneously regenerated in vivo by using a novel double-network gel: Comparisons with the normal articular cartilage How to induce cartilage regeneration. A cylindrical osteochondral defect having a diameter of 4.3-mm was created in the femoral groove. Then, a DN gel plug was implanted into the defect so that a defect having approximately 2-mm depth from the articular surface remained in place after surgery.Back to article page