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Figure 6 | BMC Musculoskeletal Disorders

Figure 6

From: Molecular changes in articular cartilage and subchondral bone in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis

Figure 6

Up-regulation of transcription factors mediating bone anabolism, runx2 and osterix in the rat surgical models of OA. Bone formation marker runx2 (a) and its downstream target osterix (b) were up-regulated during the later stage of disease progression in ACLT+MMx by ~ 2-fold in wk 4 post-surgery, and in ACLT by ~ 2-fold in wk 6 post-surgery relative to Sham. All values are shown as mean ± SD.

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