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Table 4 The effect of intervention on change in cartilage defect score from baseline to follow up

From: Effects of Hylan G-F 20 supplementation on cartilage preservation detected by magnetic resonance imaging in osteoarthritis of the knee: a two-year single-blind clinical trial

    Mean     Adjusted mean*  
  Intervention
Mean (SD)
Control
Mean (SD)
Difference†
Mean (95% CI)
P value† Intervention
Mean (SE)
Control
Mean (SE)
Difference†
Mean (95% CI)
P value†
From baseline to 12 month follow up         
Medial tibiofemoral 0.4 (0.7) 0.1 (0.5) -0.3 (-0.6, 0.1) 0.11 0.4 (0.1) 0.1 (0.1) -0.3 (-0.6, 0.1) 0.15
Lateral tibiofemoral 0.2 (0.4) 0.2 (1.0) 0.04 (-0.4, 0.5) 0.85 0.2 (0.2) 0.2 (0.1) -0.1 (-0.5, 0.4) 0.78
From baseline to 24 month follow up         
Medial tibiofemoral 0.1 (1.3) 0.8 (1.5) 0.8 (0, 1.5) 0.05 0.04 (0.3) 0.9 (0.3) 0.8 (0, 1.7) 0.05
Lateral tibiofemoral 0.4 (1.3) 0.8 (1.4) 0.4 (-0.4, 1.1) 0.33 0.5 (0.3) 0.7 (0.2) 0.2 (-0.5, 0.9) 0.56
  1. *Estimated marginal mean, adjusting for age, gender, body mass index, and baseline cartilage defect score
  2. †for difference between intervention and control groups