Skip to main content

Table 3 The effect of intervention on annual percentage change in tibial cartilage volume

From: Effects of Hylan G-F 20 supplementation on cartilage preservation detected by magnetic resonance imaging in osteoarthritis of the knee: a two-year single-blind clinical trial

    Mean     Adjusted mean*  
  Intervention
Mean (SD)
Control
Mean (SD)
Difference†
Mean (95% CI)
P value† Intervention
Mean (SE)
Control
Mean (SE)
Difference†
Mean (95% CI)
P value†
From baseline to 12 month follow up         
Medial tibial cartilage 1.4 (5.2) 3.3 (4.4) 1.9 (-0.7, 4.5) 0.15 1.3 (1.0) 3.3 (0.9) 2.0 (-0.8, 4.9) 0.16
Lateral tibial cartilage 2.8 (6.8) 1.0 (5.9) -1.8 (-5.3, 1.6) 0.29 3.3 (1.3) 0.6 (1.1) -2.7 (-6.2, 0.7) 0.12
From baseline to 24 month follow up         
Medial tibial cartilage -0.3 (2.7) 2.3 (2.6) 2.6 (1.2, 4.1) 0.001 -0.4 (0.6) 2.4 (0.5) 2.7 (1.2, 4.3) 0.001
Lateral tibial cartilage -1.4 (4.3) 1.4 (2.6) 2.8 (0.9, 4.7) 0.005 -1.3 (0.7) 1.3 (0.6) 2.6 (0.6, 4.5) 0.01
  1. *Estimated marginal mean, adjusting for age, gender, body mass index, baseline tibial cartilage volume and bone area
  2. †for difference between intervention and control groups