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Table 3 The effect of intervention on annual percentage change in tibial cartilage volume

From: Effects of Hylan G-F 20 supplementation on cartilage preservation detected by magnetic resonance imaging in osteoarthritis of the knee: a two-year single-blind clinical trial

   

Mean

   

Adjusted mean*

 
 

Intervention

Mean (SD)

Control

Mean (SD)

Difference†

Mean (95% CI)

P value†

Intervention

Mean (SE)

Control

Mean (SE)

Difference†

Mean (95% CI)

P value†

From baseline to 12 month follow up

        

Medial tibial cartilage

1.4 (5.2)

3.3 (4.4)

1.9 (-0.7, 4.5)

0.15

1.3 (1.0)

3.3 (0.9)

2.0 (-0.8, 4.9)

0.16

Lateral tibial cartilage

2.8 (6.8)

1.0 (5.9)

-1.8 (-5.3, 1.6)

0.29

3.3 (1.3)

0.6 (1.1)

-2.7 (-6.2, 0.7)

0.12

From baseline to 24 month follow up

        

Medial tibial cartilage

-0.3 (2.7)

2.3 (2.6)

2.6 (1.2, 4.1)

0.001

-0.4 (0.6)

2.4 (0.5)

2.7 (1.2, 4.3)

0.001

Lateral tibial cartilage

-1.4 (4.3)

1.4 (2.6)

2.8 (0.9, 4.7)

0.005

-1.3 (0.7)

1.3 (0.6)

2.6 (0.6, 4.5)

0.01

  1. *Estimated marginal mean, adjusting for age, gender, body mass index, baseline tibial cartilage volume and bone area
  2. †for difference between intervention and control groups