Effects of Hylan G-F 20 supplementation on cartilage preservation detected by magnetic resonance imaging in osteoarthritis of the knee: a two-year single-blind clinical trial

Table 2 Baseline characteristics of participants who completed 2 year follow up

	Intervention n = 25	Control n = 30	P value*
Age, years	61.6 (9.4)	61.3 (9.5)	0.89
Females, number (%)	15 (60)	12 (40)	0.14†
Body mass index, kg/m²	30.3 (3.9)	28.9 (4.5)	0.23
Kellgren-Lawrence grade, number (%)			0.10
2	16 (64)	25 (83)
3	9 (36)	5 (17)
Joint space narrowing, number (%)	24 (96)	29 (97)	0.90
Medial tibial cartilage volume, mm³	1488 (540)	1439 (619)	0.76
Lateral tibial cartilage volume, mm³	1485 (748)	1881 (720)	0.05
Medial tibial plateau bone area, mm²	2359 (415)	2503 (515)	0.27
Lateral tibial plateau bone area, mm²	1738 (325)	1827 (409)	0.38
Medial tibiofemoral cartilage defect score	4 [1, 8]	6 [1, 8]	0.08§
Lateral tibiofemoral cartilage defect score	4 [1, 8]	2.5 [0, 8]	0.23§
Prevalence of medial tibiofemoral bone marrow lesions, number (%)**	9 (38)	18 (72)	0.02†
Prevalence of lateral tibiofemoral bone marrow lesions, number (%)**	7 (29)	8 (32)	0.83†

Data were reported as mean (SD), median [range], or number (%)
*for difference between intervention and control groups using independent samples t test, Mann-Whitney U test§, or chi-squared test† where appropriate
**Bone marrow lesion data available in 24 subjects of intervention group and 25 subjects of control group who completed 24 month follow up

ISSN: 1471-2474