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Table 2 Parameters for trabecular bone were measured below the growth plate at the proximal metaphysis of the tibia in Toluidine-Blue and calcein double-labeled sections.

From: Hyperadiponectinemia enhances bone formation in mice

 

WT

Ad-Tg Line 11

Ad-Tg Line 13

BV/TV (%)

12.6 ± 2.7

16.1 ± 2.5*

17.3 ± 1.7**

Tb.N (/mm)

3.3 ± 0.3

3.9 ± 0.4*

3.9 ± 0.5*

OS/BS (%)

7.1 ± 4.1

17.7 ± 4.9**

15.4 ± 3.5*

O.Th (μm)

2.8 ± 0.2

3.3 ± 0.1**

2.8 ± 0.2

Ob.S/BS (%)

3.3 ± 2.8

7.4 ± 2.2*

9.3 ± 5.4**

N.Oc/B.Pm (/100 mm)

123.7 ± 41.1

112.2 ± 41.8

132.1 ± 60.7

Oc.S/BS (%)

1.0 ± 0.5

1.1 ± 0.7

1.4 ± 0.5

ES/BS (%)

2.7 ± 1.4

3.3 ± 1.5

4.4 ± 1.1

MAR (μm/day)

1.4 ± 0.2

1.7 ± 0.1**

1.6 ± 0.1*

MS/BS (%)

19.1 ± 3.2

33.1 ± 2.9**

26.8 ± 5.2*

BFR/BS (mm3/mm2/year)

0.09 ± 0.02

0.18 ± 0.03**

0.14 ± 0.03**

dLS/BS (%)

7.0 ± 1.0

20.7 ± 2.0**

14.6 ± 4.2**

  1. BV/TV, bone volume/total tissue volume; Tb. N, trabecular number; OS/BS, osteoid surface/bone surface; O.Th, osteoid thickness; Ob.S/BS, osteoblast surface/bone surface; N.Oc/B.Pm, osteoclast number/bone perimeter; Oc.S/BS, osteoclast surface/bone surface; ES/BS, eroded surface/bone surface; MAR, mineral apposition rate; MS/BS (mineralization ratio), mineralizing surface/bone surface; BFR/BS, bone formation rate/bone surface; dLS/BS, double labeled surface/bone surface. Data are expressed as means ± S.D. of 8 bones/group. *P < 0.05, **P < 0.01, significantly different from WT mice.