Table 4 Genotypes and allelic frequencies of PAI-1 gene polymorphisms between ONFH subtype patients (n = 206) and controls (n = 251)
From: Significant associations of PAI-1 genetic polymorphisms with osteonecrosis of the femoral head
Patients | p | |||||||
|---|---|---|---|---|---|---|---|---|
Position | Genotype | Controls | Idia | Alcb | Stec | vs Idi | Alc | Ste |
g.-844G/A | G | 329(65.5) | 107(54.6) | 83(57.6) | 41(56.9) | 0.007 | 0.082 | 0.154 |
(rs2227631) | A | 173(34.5) | 89(45.4) | 61(42.4) | 31(43.1) | |||
GG+GA | 213(84.9) | 75(76.5) | 61(84.7) | 28(77.8) | 0.066 | 0.977 | 0.279 | |
AA | 38(15.1) | 23(23.5) | 11(15.3) | 8(22.2) | ||||
g.-6754G/5G | 5G | 222(44.2) | 76(38.8) | 50(34.7) | 27(37.5) | 0.191 | 0.042 | 0.282 |
(rs1799889) | 4G | 280(55.8) | 120(61.2) | 94(65.3) | 45(62.5) | |||
4G5G+5G5G | 176(70.1) | 61(62.2) | 41(56.9) | 22(61.1) | 0.157 | 0.036 | 0.274 | |
4G4G | 75(29.9) | 37(37.8) | 31(43.1) | 14(38.9) | ||||
g.10700C/T | T | 274(54.6) | 88(44.9) | 62(43.1) | 33(45.8) | 0.021 | 0.015 | 0.164 |
(rs11178) | C | 228(45.4) | 108(55.1) | 82(56.9) | 39(54.2) | |||
TT+CT | 195(77.7) | 66(67.3) | 47(65.3) | 25(69.4) | 0.046 | 0.032 | 0.274 | |
CC | 56(22.3) | 32(32.7) | 25(34.7) | 11(30.6) | ||||