Figure 1
From: Zoledronic acid inhibits vasculogenic mimicry in murine osteosarcoma cell line in vitro
The effect of ZA on the development of vasculogenic mimicry by LM8 osteosarcoma cells in vitro. The LM8 osteosarcoma cells were seeded on type I collagen gel plaques. They were treated with the vehicle control or 5 μmol/L ZA for 24 hours. The cellular structure was observed under an inverted contrast microscope (A and B, X100) or with a scanning electron microscope (C and D, X2000). E: Zoomed-in area of C.