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Table 1 Characteristics of study sample at baseline, according to treatment allocation†

From: A randomized controlled trial of vitamin D dosing strategies after acute hip fracture: No advantage of loading doses over daily supplementation

 

Placebo

n = 21

50,000

n = 22

100,000

n = 22

Missing Cases (Placebo/50,000/100,000)

Age in years

78.5 (10.3)

82.9 (8.7) *

73.9(12.4) *

1/0/0

   Male (SD)

77.9 (8.4)

77.9 (11.2)

69.5 (12.9)

 

   Female (SD)

78.8 (11.5)

85.2 (6.4)

81.7 (6.6)

 

Gender

   

1/0/0

   Male (%)

7 (35)

7 (32)

14 (64)

 

   Female (%)

13 (65)

15 (68)

8 (36)

 

Height, cm

163.8 (11.4)

162.9 (10.1)

169.7 (12.6)

2/3/2

   Male (SD)

174.8 (10.2)

173.5 (4.7)

175.0 (10.3)

 

   Female (SD)

158.7 (7.9)

156.7 (6.3)

158.2 (7.3)

 

Weight, kg

70.6 (25.4)

64.8 (18.1)

72.1 (15.8)

2/2/2

   Male (SD)

89.1 (30.3)

79.4 (12.7)

76.1 (10.8)

 

   Female (SD)

62.1(18.4)

57.0 (15.8)

64.6 (21.4)

 

Prior Smoking (%)

9 (50)

7 (39)

11 (58)

3/4/3

Previous fracture documented (%)

3 (15)

5 (23)

6 (27)

1/0/0

Prior vitamin D use (%)

4 (20)

1 (4.5)

4 (18)

1/0/0

Prior calcium use (%)

5 (25)

2 (9)

4 (18)

1/0/0

Number of medications at admission (SD)

6.2 (4.6)

6.0 (3.8)

5.0 (4.4)

1/0/0

Charlson index (SD)

1.30 (1.13)

0.82 (1.18)

0.55 (0.80)

2/0/0

Ambulatory without aids prior to admission (%)

8 (44)

13 (72)

13 (68)

3/4/3

Total calcium, mmol/L (SD)

2.10 (0.14)

2.12 (0.11)

2.08 (0.14)

1/1/0

Hb, g/L (SD)

108.6 (15.2)

102.2 (14.3)

107.9 (17.4)

1/0/0

Albumin, g/L (SD)

34.1 (6.0)

33.0 (5.8)

32.4 (5.4)

1/5/4

Creatinine, umol/L (SD)

73.7 (37.0)

70.5 (23.8)

77.4 (26.1)

1/0/0

Phosphate, mmol/L (SD)

0.94 (0.27)

0.86 (0.22)

0.97 (0.24)

1/0/0

Alkaline phosphatase, U/L (SD)

98.6 (37.8)

78.7 (26.2)

79.4 (51.1)

1/0/0

Parathyroid Hormone (PTH), pmol/L (SD)

4.20 (2.12)

5.35 (3.01)

5.10 (3.91)

1/0/0

  1. *Significant difference between groups, p <0.05.
  2. †Refers to loading dose of vitamin D2 at baseline; all groups received 1,000 IU vitamin D3 /daily following loading dose.
  3. Values are the mean (SD), or number (%)