Figure 5

H&E-stained sections of gastrocnemius muscles (GMs). H&E-stained sections of gastrocnemius muscles (GMs) isolated from: (a) wild-type (w.t.) mice at (i) baseline (6 weeks old), (ii) week 8, (iii) week 14, and (iv) at the termination of the study (20-22 weeks of age). Pathology is described in the text. Legend: solid arrow, points to eccentrically-located nuclei in myofibers; (b) non-exercised mdx at (i) baseline, (ii) week 8, (iii) week 14, and (iv) at the termination of the study. Legend: open arrowhead points to centrally-located nuclei in myofibers; closed arrowhead points to inflammatory infiltrate, solid arrow points to eccentrically-located nuclei in myofibers; (c) exercised mdx mice at (i) baseline, (ii) week 8, (iii) week 14, and (iv) at the termination of the study. The pathology observed in each group and at each time are described in the text. Legend: solid arrow points to eccentrically-located nuclei; open arrowhead points to centrally-located nuclei in myofibers; closed arrowhead points to inflammatory infiltrate; and thin solid arrow points to a mineralized lesion; (d) non-exercise udx mice at (i) baseline, (ii) week 8, (iii) week 14, and (iv) at the termination of the study. Legend: open arrowhead points to centrally-located nuclei in myofibers; closed arrowhead points to inflammatory infiltrate.