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Table 1 Impregnation of bone chips with cefazolin and vancomycin solutions

From: Impregnation of bone chips with antibiotics and storage of antibiotics at different temperatures: an in vitro study

Antibiotic Rinsing with 0.9% saline, +/- Antibiotic content of impregnation fluid
(μg/5 ml)
Mean diameter of S. epidermidis-free zone (mm) Mean antibiotic content of 1.0 g of bone chips
(μg)
Cefazolin + 1000 28.0 ± 1.2 32
  + 750 23.6 ± 1.3 15
  + 500 23.0 ± 1.2 13
  + 250 19.6 ± 0.5 7
  - 1000 32.4 ± 0.9 105
  - 750 31.8 ± 0.8 92
  - 500 29.0 ± 2.4 44
  - 250 28.6 ± 0.5 39
Vancomycin + 5000 23.2 ± 0.5 214
  + 2500 22.0 ± 1.0 212
  + 1000 17.8 ± 1.1 204
  + 250 7.6 ± 6.9 178
  - 5000 24.2 ± 0.8 215
  - 2500 23.6 ± 1.1 214
  - 1000 22.8 ± 3.3 212
  - 250 16.0 ± 0.7 201
  1. Antibiotic quantity of 1.0 g bone chips, with and without rinsing of the bone chips, is calculated using the regression analysis of the antibiotic solution (figure 5).