Table 1 Impregnation of bone chips with cefazolin and vancomycin solutions
Antibiotic | Rinsing with 0.9% saline, +/- | Antibiotic content of impregnation fluid (μg/5 ml) | Mean diameter of S. epidermidis-free zone (mm) | Mean antibiotic content of 1.0 g of bone chips (μg) |
|---|---|---|---|---|
Cefazolin | + | 1000 | 28.0 ± 1.2 | 32 |
+ | 750 | 23.6 ± 1.3 | 15 | |
+ | 500 | 23.0 ± 1.2 | 13 | |
+ | 250 | 19.6 ± 0.5 | 7 | |
- | 1000 | 32.4 ± 0.9 | 105 | |
- | 750 | 31.8 ± 0.8 | 92 | |
- | 500 | 29.0 ± 2.4 | 44 | |
- | 250 | 28.6 ± 0.5 | 39 | |
Vancomycin | + | 5000 | 23.2 ± 0.5 | 214 |
+ | 2500 | 22.0 ± 1.0 | 212 | |
+ | 1000 | 17.8 ± 1.1 | 204 | |
+ | 250 | 7.6 ± 6.9 | 178 | |
- | 5000 | 24.2 ± 0.8 | 215 | |
- | 2500 | 23.6 ± 1.1 | 214 | |
- | 1000 | 22.8 ± 3.3 | 212 | |
- | 250 | 16.0 ± 0.7 | 201 |