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Table 3 Histological disease scoring of wildtype mice treated with the specific PI3Kγ inhibitor AS-605240 during AIA (n = 5, mean ± SEM)

From: Loss of phosphoinositide 3-kinase γ decreases migration and activation of phagocytes but not T cell activation in antigen-induced arthritis

 

day 2

day 7

 

control

AS-605240

control

AS-605240

acute inflammation

3,0 ± 1,0

1,9 ± 0,8

2,5 ± 1,0

2,5 ± 0,8

chronic inflammation

1,9 ± 0,6

1,4 ± 0,6

2,2 ± 0,7

2,2 ± 0,4

Destruction

1,1 ± 0,1

0,8 ± 0,2

1,3 ± 0,4

1,0 ± 0,3

total score

6,0 ± 1,1

4,1 ± 0,6

6,0 ± 0,6

5,7 ± 0,8

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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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