Stimulation of human OA cartiage explants with salmon caltionin increase the release of pro-peptides of type II collagen. Human OA cartilage explants were cultured for 16 days with different doses of salmon calcitonin and IGF as positiv control. The released neoepitopes in the supernatant from day 16, were quatifiened by an ELISA detecting the N-terminal collagen type II pro-peptides, PIINP. The bars represent the mean value from 6-replicates and the indivdual values were adjusted for the amount of cultured cartilage. The errorbars are the standard error of mean, SEM. The asterisk symbolize the levels of statistical difference to the vehicle control, * P < 0.05. **P < 0.01.