Treatment with raloxifene decreased the serum levels of IL-6 and COMP. Scatter plots showing the serum levels of IL-6 (A) and cartilage oligomeric matrix protein (COMP) (B) in mice with CIA treated with raloxifene (60 μg/day), E2 (1 μg/day) or vehicle Miglyol812 (100 μl/day). n = 11-15 in each group. Lines represent medians. Kruskall-Wallis test with post hoc comparison was used, *P < 0.05, **P < 0.01, ***P < 0.001.