Treatment with raloxifene or estradiol protected arthritic mice from osteoporosis. Scatter plots showing the trabecular bone mineral density (BMD) (A) and the cortical BMD (B), measured with peripheral quantitative computer tomography (pQCT) in mice with CIA treated with raloxifene (60 μg/day), E2 (1 μg/day) or vehicle Miglyol812 (100 μl/day), n = 11-15 in each group. Lines represent medians. Kruskall-Wallis test with post hoc comparison was used, *P < 0.05, **P < 0.01, ***P < 0.001. C: Representative pQCT scans of cross-sections of the femur, showing the bone mineral density (BMD). The pictures show one representative mouse in each treatment group. The bar shows the density of the bone, from 0 (black) to >750 mg/cm3 (white).