Enhancement of antinociception by coadminstration of minocycline and a non-steroidal anti-inflammatory drug indomethacin in naïve mice and murine models of LPS-induced thermal hyperalgesia and monoarthritis

Table 3 Percentage of change from baseline reaction latency times of BALBc mice at 1 hour post-drug treatment with minocycline plus selective COX inhibitors in the hot plate test.

Drug and dose administered to mice	% Change in reaction latency (mean ± S.E.M of the values obtained from 8 to 11 animals.)^#	Statistical significance^§
Vehicles (for COX inhibitors and minocycline)	-5.11 ± 4.05 (n = 10)
selective COX-1 inhibitor, FR122047 10 mg/kg	4.33 ± 6.81 (n = 11)	ns
selective COX-2 inhibitor, CAY10404 10 mg/kg	12.85 ± 6.29 (n = 8)	ns
Minocycline 50 mg/kg	-26.34 ± 3.35 (n = 9)	**
FR122047 10 + minocycline 50 mg/kg	-11.68 ± 4.61 (n = 11)	ns, nz
CAY10404 10 + minocycline 50 mg/kg	24.22 ± 5.81 (n = 10)	**, # #

^# (response latency after drug treatment - baseline latency)/baseline latency × 100.
^§ Statistically significant differences in comparison with drug vehicle: ** p < 0.01; ns: no statically significant differences in comparison with drug vehicle; statistically significant differences between minocycline alone and the combination of minocycline + selective COX inhibitor treatments: ^{# #} p < 0.01; nz: no statically significant differences in comparison with minocycline alone (one-way ANOVA followed by Newman-Keuls test).

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