Skip to main content

Table 3 Percentage of change from baseline reaction latency times of BALBc mice at 1 hour post-drug treatment with minocycline plus selective COX inhibitors in the hot plate test.

From: Enhancement of antinociception by coadminstration of minocycline and a non-steroidal anti-inflammatory drug indomethacin in naïve mice and murine models of LPS-induced thermal hyperalgesia and monoarthritis

Drug and dose administered to mice % Change in reaction latency (mean ± S.E.M of the values obtained from 8 to 11 animals.)# Statistical significance§
Vehicles (for COX inhibitors and minocycline) -5.11 ± 4.05 (n = 10)  
selective COX-1 inhibitor, FR122047 10 mg/kg 4.33 ± 6.81 (n = 11) ns
selective COX-2 inhibitor, CAY10404 10 mg/kg 12.85 ± 6.29 (n = 8) ns
Minocycline 50 mg/kg -26.34 ± 3.35 (n = 9) **
FR122047 10 + minocycline 50 mg/kg -11.68 ± 4.61 (n = 11) ns, nz
CAY10404 10 + minocycline 50 mg/kg 24.22 ± 5.81 (n = 10) **, # #
  1. # (response latency after drug treatment - baseline latency)/baseline latency × 100.
  2. § Statistically significant differences in comparison with drug vehicle: ** p < 0.01; ns: no statically significant differences in comparison with drug vehicle; statistically significant differences between minocycline alone and the combination of minocycline + selective COX inhibitor treatments: # # p < 0.01; nz: no statically significant differences in comparison with minocycline alone (one-way ANOVA followed by Newman-Keuls test).