Table 1 Percentage of change from baseline reaction latency of BALB/c mice at 1 hour post-drug treatment in the hot plate test.
Drug and dose administered to mice | % Change in reaction latency (mean ± S.E.M of the values obtained from 6 to 16 animals.)# | Statistical significance§ |
|---|---|---|
Vehicle for indomethacin | -4.64 ± 4.619 (n = 7) | |
Indomethacin 5 mg/kg | -10.43 ± 4.11 (n = 7) | ns |
Indomethacin 10 mg/kg | -1.02 ± 3.85 (n = 7) | ns |
Indomethacin 20 mg/kg | -6.43 ± 5.75 (n = 7) | ns |
Indomethacin 50 mg/kg | 2.03 ± 10.29 (n = 7) | ns |
Vehicle for minocycline | -5.34 ± 2.68 (n = 16) | |
Minocycline 12.5 mg/kg | -6.78 ± 3.09 (n = 11) | ns |
Minocycline 25 mg/kg | -21.63 ± 2.24 (n = 11) | ** |
Minocycline 50 mg/kg | -34.16 ± 4.31 (n = 10) | ** |
Minocycline 100 mg/kg | -34.21 ± 4.08 (n = 8) | ** |
Vehicles for indomethacin and minocycline | -4.97 ± 2.51 (n = 16) | |
Indomethacin 5 + minocycline 50 mg/kg | 21.49 ± 4.70 (n = 6) | ** |
Indomethacin 10 + minocycline 50 mg/kg | 24.567 ± 4.05 (n = 16) | ** |
Indomethacin 10 + minocycline 25 mg/kg | -7.65 ± 4.97 (n = 6) | ns |