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Table 1 Percentage of change from baseline reaction latency of BALB/c mice at 1 hour post-drug treatment in the hot plate test.

From: Enhancement of antinociception by coadminstration of minocycline and a non-steroidal anti-inflammatory drug indomethacin in naïve mice and murine models of LPS-induced thermal hyperalgesia and monoarthritis

Drug and dose administered to mice % Change in reaction latency (mean ± S.E.M of the values obtained from 6 to 16 animals.)# Statistical significance§
Vehicle for indomethacin -4.64 ± 4.619 (n = 7)  
Indomethacin 5 mg/kg -10.43 ± 4.11 (n = 7) ns
Indomethacin 10 mg/kg -1.02 ± 3.85 (n = 7) ns
Indomethacin 20 mg/kg -6.43 ± 5.75 (n = 7) ns
Indomethacin 50 mg/kg 2.03 ± 10.29 (n = 7) ns
Vehicle for minocycline -5.34 ± 2.68 (n = 16)  
Minocycline 12.5 mg/kg -6.78 ± 3.09 (n = 11) ns
Minocycline 25 mg/kg -21.63 ± 2.24 (n = 11) **
Minocycline 50 mg/kg -34.16 ± 4.31 (n = 10) **
Minocycline 100 mg/kg -34.21 ± 4.08 (n = 8) **
Vehicles for indomethacin and minocycline -4.97 ± 2.51 (n = 16)  
Indomethacin 5 + minocycline 50 mg/kg 21.49 ± 4.70 (n = 6) **
Indomethacin 10 + minocycline 50 mg/kg 24.567 ± 4.05 (n = 16) **
Indomethacin 10 + minocycline 25 mg/kg -7.65 ± 4.97 (n = 6) ns
  1. # (response latency after drug treatment - baseline latency)/baseline latency × 100.
  2. §Statistically significant differences in comparison with drug vehicle: ** p < 0.01; ns: no statically significant differences in comparison with drug vehicle (one-way ANOVA followed by Newman-Keuls test).