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Figure 4 | BMC Musculoskeletal Disorders

Figure 4

From: Enhancement of antinociception by coadminstration of minocycline and a non-steroidal anti-inflammatory drug indomethacin in naïve mice and murine models of LPS-induced thermal hyperalgesia and monoarthritis

Figure 4

Coadministration of minocycline with indomethacin alleviates weight bearing deficits in mice with LPS-induced monoarthritis. Effects of indomethacin 1 mg/kg, minocycline 50 mg/kg or a combination of minocycline 50 mg/kg plus indomethacin 1 mg/kg on A: weight bearing (measured as ratio of light intensity between right hind (RH) and left hind (LH) limbs) and B: ratio of RH/LH print area of mice with LPS-induced arthritis. The drugs or their vehicles were administered at 2 days post-LPS administration and their effects measured at 1 hour after drug treatment. Each point represents the mean ± S.E.M of the values obtained from 6 to 9 animals. Non-arthritic control (n = 9) and arthritic mice (LPS-inoculated) treated with vehicle (n = 7), indomethacin 1 mg/kg (n = 7), minocycline 50 mg/kg (n = 8) or a combination of minocycline 50 mg/kg plus indomethacin 1 mg/kg (n = 6). Statistically significant differences in comparison with non-arthritic control (vehicle only injected) group: * p < 0.05 and ** p < 0.01 (two-way ANOVA followed by Bonferroni test). C and D: Percentage change in RH/LH light intensity and print area ratios from LPS-induced monoarthritic mice at 1 hour after drug treatment. Each bar represents the mean ± S.E.M of the values obtained from 6 to 8 animals. Arthritic mice (LPS-inoculated) treated with vehicle (n = 7), indomethacin 1 mg/kg (n = 7), minocycline 50 mg/kg (n = 8) or a combination of minocycline 50 mg/kg plus indomethacin 1 mg/kg (n = 6). Statistically significant differences in comparison with drug vehicle treated group: * p < 0.05 and ** p < 0.01; and between indomethacin or minocycline alone versus minocycline plus indomethacin combination treated mice: # p < 0.05 and # # p < 0.01 (one-way ANOVA followed by Newman-Keuls multiple comparison test).

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