Coadministration of minocycline with indomethacin produces antinociceptive effects in the hot plate test. Effect of intraperitoneal treatment with indomethacin, minocycline or a combination of minocycline plus indomethacin in a hot plate test in naïve BALB/c mice. Time course of the reaction latency times for minocycline (50 mg/kg, n = 15), indomethacin (10 mg/kg, n = 16), minocycline + indomethacin (n = 16) or their vehicles (n = 16). Each point represents the mean ± S.E.M of the values obtained from 15 to 16 animals. Statistically significant differences in comparison with drug vehicle: * p < 0.05 and ** p < 0.01; and between minocycline or indomethacin and the combination of minocycline + indomethacin treatments: # p < 0.05 and # # p < 0.01 (two-way ANOVA followed by Bonferroni test).