Figure 9

Primary human osteoblasts transfected with siRNA and scrambled control exposed to dexamethasone in vitro compared with respect to alkaline phosphatase activity over a 72 h time course. Significant increases in alkaline phosphatase activity relative to scrambled control identified at 12 h, 24 h, 48 h and 72 h of dexamethasone exposure. *p < 0.05, **p < 0.01 versus scrambled control.