The time course of changes in the hand-grip muscle strength of patients 1 and 2 before and after treatment with rituximab. The right and left hand-grip muscle strength is expressed as a percentage of the mean values obtained from a group of 16 healthy male subjects, regarded as baseline, and taken with the value 100%. The upper and lower left panels show the right and left hand grip muscle strength values of patients 1 and 2 at days -365, -300, -150 and -90 before the treatment. Patient 1 was evaluated four times during the course of treatment and again after about one year. The percentage improvement in the patient was around 13% compared to the normal reference value, and the highest percentage increase in strength occurred after 7-14 days. Patient 2 was evaluated three times during the course of treatment and again approximately eight months after treatment. The percentage improvement of the patient compared to the normal reference value was around 58% and the highest percentage increase of distal muscle strength (20%) occurred after 35 days.