|
Variable Measured
|
Cohorts 1&2 (N = 4)
|
Cohort 3 (N = 13)
|
|---|
| |
Visit 1
|
Visit 2
|
P**
|
Visit 1
|
Visit 2
|
P
|
|---|
|
BP Syst (mm Hg)
|
124 ± 7.3
|
137 ± 5.9
|
0.14
|
129 ± 4.0
|
130 ± 5.7
|
0.78
|
|
BP Diast (mm Hg)
|
92 ± 8.6
|
90 ± 6.2
|
0.94
|
85 ± 2.4
|
85 ± 3.6
|
1.0
|
|
HR (BPM)
|
74 ± 6.0
|
66 ± 5.2
|
0.010
|
71 ± 4.1
|
74 ± 4.0
|
0.36
|
|
WBC (cell/mm3)
|
6.2*
|
5.9
|
--
|
7.1 ± 0.68
|
6.2 ± 0.67
|
0.002
|
|
Hemoglobin (g/dL)
|
14.1*
|
13.8
|
--
|
14.3 ± 0.3
|
13.8 ± 0.3
|
0.02
|
|
Creatinine (mg/dL)
|
0.8*
|
0.75
|
--
|
0.84 ± 0.06
|
0.86 ± 0.07
|
0.35
|
|
AST (U/L)
|
20.5*
|
21.5
|
---
|
23.9 ± 1.0
|
23.3 ± 5.1
|
0.56
|
- * Only 2 placebo patients in cohorts 1,2 had paired blood samples, so SEM and P valuescould not be calculated.
