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Table 3 Safety measures at visit 1 and visit 2 in patients receiving placebo

From: Phase 1, placebo-controlled, dose escalation trial of chicory root extract in patients with osteoarthritis of the hip or knee

Variable Measured Cohorts 1&2 (N = 4) Cohort 3 (N = 13)
  Visit 1 Visit 2 P** Visit 1 Visit 2 P
BP Syst (mm Hg) 124 ± 7.3 137 ± 5.9 0.14 129 ± 4.0 130 ± 5.7 0.78
BP Diast (mm Hg) 92 ± 8.6 90 ± 6.2 0.94 85 ± 2.4 85 ± 3.6 1.0
HR (BPM) 74 ± 6.0 66 ± 5.2 0.010 71 ± 4.1 74 ± 4.0 0.36
WBC (cell/mm3) 6.2* 5.9 -- 7.1 ± 0.68 6.2 ± 0.67 0.002
Hemoglobin (g/dL) 14.1* 13.8 -- 14.3 ± 0.3 13.8 ± 0.3 0.02
Creatinine (mg/dL) 0.8* 0.75 -- 0.84 ± 0.06 0.86 ± 0.07 0.35
AST (U/L) 20.5* 21.5 --- 23.9 ± 1.0 23.3 ± 5.1 0.56
  1. * Only 2 placebo patients in cohorts 1,2 had paired blood samples, so SEM and P valuescould not be calculated.
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