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Table 3 Safety measures at visit 1 and visit 2 in patients receiving placebo

From: Phase 1, placebo-controlled, dose escalation trial of chicory root extract in patients with osteoarthritis of the hip or knee

Variable Measured

Cohorts 1&2 (N = 4)

Cohort 3 (N = 13)

 

Visit 1

Visit 2

P**

Visit 1

Visit 2

P

BP Syst (mm Hg)

124 ± 7.3

137 ± 5.9

0.14

129 ± 4.0

130 ± 5.7

0.78

BP Diast (mm Hg)

92 ± 8.6

90 ± 6.2

0.94

85 ± 2.4

85 ± 3.6

1.0

HR (BPM)

74 ± 6.0

66 ± 5.2

0.010

71 ± 4.1

74 ± 4.0

0.36

WBC (cell/mm3)

6.2*

5.9

--

7.1 ± 0.68

6.2 ± 0.67

0.002

Hemoglobin (g/dL)

14.1*

13.8

--

14.3 ± 0.3

13.8 ± 0.3

0.02

Creatinine (mg/dL)

0.8*

0.75

--

0.84 ± 0.06

0.86 ± 0.07

0.35

AST (U/L)

20.5*

21.5

---

23.9 ± 1.0

23.3 ± 5.1

0.56

  1. * Only 2 placebo patients in cohorts 1,2 had paired blood samples, so SEM and P valuescould not be calculated.