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Table 1 Demographic and disease features at baseline in 3 cohorts

From: Phase 1, placebo-controlled, dose escalation trial of chicory root extract in patients with osteoarthritis of the hip or knee

VARIABLES COHORTS P VALUES*
  1 2 3  
Age (years) 59 ± 2 64 ± 4 65 ± 2 0.28
Gender F/M 9/0 (100%) 5/3 (62.5%) 16/7 (70%) 0.133
Non-Hispanic Caucasian 67% 75% 91% 0.21
BMI 35.3 ± 4.6 30.4 ± 1.6 29.6 ± 1.2 0.20
Knee/Hip 8/1 5/3 20/3 0.60
Walking Time (sec) 12.0 ± 2.6 7.3 ± 0.7 7.7 ± 0.4 0.009
WOMAC Item #1 3.2 ± 0.3 2.4 ± 0.3 3.9 ± 0.4 0.075
WOMAC Item #5 3.2 ± 0.3 2.4 ± 0.3 2.4 ± 0.2 0.047
BPI ** 5.6 ± 0.9 2.6 ± 0.7 3.9 ± 0.4 0.19
Global VAS (mm) 54.5 ± 10.9 31.0 ± 6.7 45.8 ± 4.4 0.15
Modified HAQ (0-3 scale) 1.4 ± 0.2 0.7 ± 0.1 0.8 ± 0.1 0.17
Hemoglobin (g/dL) 13.0 ± 0.5 14.2 ± 0.4 14.4 ± 0.2 0.016
Creatinine (mg/dL) 0.77 ± 0.06 0.80 ± 0.09 0.82 ± 0.03 0.74
AST (U/L) 19 ± 1 23 ± 2 24 ± 2 0.32
  1. *P values for Age and BMI calculated with one-way ANOVA or Fisher's Exact Test.
  2. **BPI Score is mean for items 3-6 and 9(A-G).
  3. Normal ranges: Hemoglobin 13.2-16.2 g/dL; creatinine 0.7-1.2 mg/dL; AST 13-40 U/L.
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