Table 1 Gene and protein expression in HU mice and recovery versus control.
mRNA Vs. control | HU7 | HU14 | HU14+R14 | expressed in |
|---|---|---|---|---|
AP | ↓ | ↓ | ↓ | growth plate chondrocytes, osteogenic, bone marrow cells |
OC | ↓ | = | = | growth plate chondrocytes, osteogenic, bone marrow cells |
MT1-MMP | ↑ | ↑ | = | growth plate chondrocytes, osteogenic, bone marrow cells |
MMP9 | = | ↓ | = | growth plate chondrocytes, osteogenic, bone marrow cells, macrophages |
BMP1 | = (ns) | ↓ | = | growth plate chondrocytes, osteogenic, bone marrow cells |
PCOLCEs | = | ↓ | = (↓distal bone marrow) | growth plate chondrocytes, osteogenic, bone marrow cells |
CXCR4 | = (ns) | ↑ | = | osteogenic, bone marrow cells |
Protein vs. control | HU7 | HU14 | HU14+R14 | expressed in |
OC | ND | ↓ | = | growth plate chondrocytes, osteogenic, bone marrow cells |
BSP | ↓ | = (↓osteoblasts) | ND | osteogenic, bone marrow cells |
RECK | ↓ | = | ND | osteogenic cells |
BMP1 | = (ns) | ↓ | = | growth plate chondrocytes, osteogenic, bone marrow cells |
Stro1 | ↑ | = | ND | osteogenic, bone marrow cells |
CXCL12 | ND | ↓ | = (only osteoblasts) | bone marrow cells |