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Figure 4 | BMC Musculoskeletal Disorders

Figure 4

From: Alterations in osteoclast function and phenotype induced by different inhibitors of bone resorption - implications for osteoclast quality

Figure 4

Evaluation of MMP generated resorption and MMP secretion. Mature human osteoclasts were seeded on bone slices and cultured for 5 days in the presence or absence of the indicated inhibitors. A) ICTP levels were measured in culture supernatants. B) Gelatinase zymografi of pooled culture supernatants. MMP-9 is used as marker. A representative gel is shown. Based on analysis of three individual gels in ImageJ, relative band intensities, reflecting MMP-9 activity, were calculated. Relative intensities are given ± SD.

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