Figure 4

Effects on the bone mechanical properties of femoral midshaft in OVX rats. Starting 12 weeks after OVX, drugs were administered orally to rats for 12 weeks. The ultimate load, the stiffness and the energy in the femoral midshaft was determined, as described in MATERIALS AND METHODS. Each value represents the mean ± SE (n = 7–8). *p < 0.05, **p < 0.01, ***p < 0.001 compared with the OVX-control group. Note that the combination therapy with ALF and RIS increased the ultimate load and the energy at femoral midshaft more than ALF alone (p < 0.001).