Figure 5

Inhibition of Disease Progression by Treatment with 2ME2. On study day 21, periarticular inflammatory infiltrates (arrow heads), fibrosis (asterisks) and osteophyte (arrows) are readily apparent in mouse tissue following induction with monoclonal antibodies to type II collagen and treatment with vehicle control (A). In contrast, treatment of mice with 100 mg/kg/day 2ME2 resulted in abrogation of these histopathologic changes and the appearance of normal architecture (B). Loss of articular proteoglycan (arrows) and induction of osteoclast activity (asterisk) were observed in tissue from mice treated with vehicle control (C). In contrast, treatment of mice with 100 mg/kg/day 2ME2 resulted in abrogation of these histopathologic changes and the appearance of normal joint architecture (D). Magnification = 60×.