Abrogation of the Articular Inflammatory Response in Mice Treated with 2ME2. On study day 8, right and left hind paws were fixed in formalin, sectioned and stained by H&E. Intense inflammation is evident in the joints of mice receiving treatment with control diluent (A). In contrast, treatment of mice with 100 mg/kg/day of 2ME2 has essentially abrogated the inflammatory response (B). Magnification = 10×.